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Table 1 Observed efficacy and induced mortality of fluralaner against sand flies 24 hours after exposure on dogs

From: A randomized, blinded, controlled trial to assess sand fly mortality of fluralaner administered orally in dogs

Direct feeding Control Fluralaner
n a Deathsbn (%) 95% CI N a Deathsbn (%) 95% CI Efficacyc(%) P-valued
Day -7 138 3 (2) 0–5 123 2 (2) 0–4 0 0.75
Day 3 147 6 (4) 0–7 151 151 (100) nae 100 <0.0001
Day 17 150 3 (2) 0–4 146 143 (98) 96–100 93 <0.0001
Day 31 148 2 (1) 0–3 159 150 (95) 91–98 94 <0.0001
Day 45 141 13 (10) 5–15 148 138 (89) 84–93 75 <0.0001
Day 73 153 34 (22) 13–28 182 75 (42) 35–49 26 <0.08
  1. aNumber of sand flies exposed to direct-feed on dogs
  2. bNumber (%) of sand flies dead 24 h after direct-feeding
  3. cEfficacy as the percentage of phlebotomine mortality due to the insecticide effect calculated according to adapted Henderson-Tilton’s formula
  4. d(Two-sided) probability values associated with the comparison on sand fly mortality between control and fluralaner using Fisher’s exact test
  5. eAll samples showed 100% death so there is no 95% CI