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Fig. 6 | Parasites & Vectors

Fig. 6

From: Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production

Fig. 6

Effects of selected HDAC inhibitors on the reproductive systems of adult S. mansoni pairs. Representative confocal scanning laser images of adult S. mansoni pairs treated for 72 h with DMSO (vehicle), SmI-148 at 5 μM, SmI-558 at 2.5 μM (testis, ovary and ootype) or 5 μM (vitellarium) and stained with carmine red. Abbreviations: sv, seminal vescicle; io, immature oocyte; mo, mature oocyte; ut, uterus; ot, ootype; vt, vitellarium. Red arrows indicate black spots in mature oocyte, white arrow indicates a deformed egg in uterus, and asterisk indicates cells accumulated in the first part of the uterus. Scale-bars: 50 μm

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Parasites & Vectors

ISSN: 1756-3305

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