Infection with Trichomonas vaginalis increases the risk of psychiatric disorders in women: a nationwide population-based cohort study

Table 6 Risk of psychiatric disorders subgroup among study population and trichomoniasis cohort identified by using Cox regression

Psychiatric disorders subgroup	Trichomoniasis visits	Study population					Trichomoniasis cohort
Psychiatric disorders subgroup	Trichomoniasis visits	Population	Event	Adjusted HR	95% CI	P	Adjusted HR	95% CI	P
Overall	0 (without trichomoniasis)	37,492	1988	Ref.
	1 trichomoniasis visit	9051	809	2.560	2.353–2.784	<0.001	Ref.
	≥ 2 trichomoniasis visits	322	66	7.676	5.953–9.898	<0.001	2.664	2.047–3.467	<0.001
Depression	0	37,492	812	Ref.
	1	9051	341	2.712	2.381–3.089	<0.001	Ref.
	≥ 2	322	30	8.306	5.667–12.173	<0.001	2.594	1.741–3.866	<0.001
Anxiety	0	37,492	553	Ref.
	1	9051	271	2.975	2.562–3.454	<0.001	Ref.
	≥ 2	322	23	10.674	6.853–16.623	<0.001	3.472	2.199–5.482	<0.001
Bipolar disorder	0	37,492	105	Ref.
	1	9051	42	2.679	1.854–3.873	<0.001	Ref.
	≥ 2	322	0	0.000	–	0.968	<0.0001	–	0.972
PTSD/ASD	0	37,492	42	Ref.
	1	9051	7	1.013	0.456–2.298	0.978	Ref.
	≥ 2	322	0	0.000	–	0.988	<0.0001	–	0.989
Schizophrenia	0	37,492	147	Ref.
	1	9051	84	3.949	2.992–5.212	<0.001	Ref.
	≥ 2	322	7	12.471	5.739–27.101	<0.001	2.806	1.260–6.247	0.012
Substance abuse	0	37,492	91	Ref.
	1	9051	80	1.535	1.301–2.011	<0.001	Ref.
	≥ 2	322	4	3.897	2.049–7.122	<0.001	3.286	1.870–5.864	<0.001
Other psychiatric disorders	0	37,492	56	Ref.
	1	9051	66	1.862	1.503–2.188	<0.001	Ref.
	≥ 2	322	11	5.897	3.402–9.864	<0.001	5.642	2.864–7.862	<0.001

Abbreviations: Adjusted HR, adjusted hazard ratio (adjusted for the variables listed in Table 1); CI, confidence interval; PTSD, post-traumatic stress disorder; ASD, acute stress disorder; Ref., reference

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