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Table 1 In vivo effect of DW-3-15 against S. japonicum infected mice

From: In vitro and in vivo activities of DW-3-15, a commercial praziquantel derivative, against Schistosoma japonicum

Group and dose (mg/kg per day)a Worm burden (Mean ± SD) Worm burden reduction (%) No. of eggs × 103/g liver tissue Egg reduction (%)
Female Male Total Female Male Total
Controlb 24.0 ± 1.9 29.0 ± 2.3 53.0 ± 3.4 23.8 ± 5.2
DW-3-15(400) 7.0 ± 2.0 12.4 ± 1.8 19.4 ± 1.7* 70.8 57.2 63.4 3.4 ± 0.5* 85.8
PZQ(400) 0 ± 0 0.6 ± 0.5 0.6 ± 0.5* 100.00 97.9 98.9 0.7 ± 0.3* 97.0
  1. aTreatment was started 35 days after infection
  2. bControl, 200 μl of ethanol:Tween80:water (3:7:90)
  3. *P < 0.05, significant difference compared to the control group
  4. Abbreviation: SD, standard deviation