Skip to main content

Advertisement

Table 2 In vivo dose response relationships of emodepside on A. ceylanicum, N. americanus and T. muris

From: Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections

  Dose (mg/kg) Mean no. of worms ± SD Worm expulsion rate (%) Worm burden reduction (%) P-value ED50 (mg/kg)
T. muris
 Emodepside 75c 0 100 100 0.007a 1.2
10c 18.8 ± 20.8 62.0 85.9  
2.5c 36.5 ± 30.8 60.9 69.6  
1.25d 133 ± 27.9 5.3 73.9  
 Control 1c   120.8 ± 12.0 0   
 Control 2d   121.7 ± 4.7 0   
A. ceylanicum
 Emodepside 2.5 0 100 100 0.014a  
 Control   21.3 ± 2.6 0.6   
N. americanus
 Emodepside 10c 0 100 100 0.060a 0.5
5c 0 100 100  
2.5d 0.25 ± 0.5 87.5 93.8  
1.25d 2.25 ± 2.3 40.0 43.8  
 Control 1c   5.5 ± 6.1 5.6   
 Control 2d   4.0 ± 1.4 0   
  1. aKruskal-Wallis test was applied to determine statistical significance on worm burden reduction of all doses versus controls
  2. cControl 1 was used for this dose
  3. dControl 2 was used for this dose