Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections

Parasites & Vectors

Table 2 In vivo dose response relationships of emodepside on A. ceylanicum, N. americanus and T. muris

	Dose (mg/kg)	Mean no. of worms ± SD	Worm expulsion rate (%)	Worm burden reduction (%)	P-value	ED₅₀ (mg/kg)
T. muris
Emodepside	75^c	0	100	100	0.007^a	1.2
	10^c	18.8 ± 20.8	62.0	85.9
	2.5^c	36.5 ± 30.8	60.9	69.6
	1.25^d	133 ± 27.9	5.3	73.9
Control 1^c		120.8 ± 12.0	0	–
Control 2^d		121.7 ± 4.7	0	–
A. ceylanicum
Emodepside	2.5	0	100	100	0.014^a
Control		21.3 ± 2.6	0.6	–
N. americanus
Emodepside	10^c	0	100	100	0.060^a	0.5
	5^c	0	100	100
	2.5^d	0.25 ± 0.5	87.5	93.8
	1.25^d	2.25 ± 2.3	40.0	43.8
Control 1^c		5.5 ± 6.1	5.6	–
Control 2^d		4.0 ± 1.4	0	–

^aKruskal-Wallis test was applied to determine statistical significance on worm burden reduction of all doses versus controls
^cControl 1 was used for this dose
^dControl 2 was used for this dose

ISSN: 1756-3305