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Table 4 In vivo dose response relationships of emodepside, albendazole, levamisole and pyrantel pamoate on A. ceylanicum, N. americanus and T. muris

From: Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections

Drug

Dose (mg/kg)

Worm expulsion rate (%)

Worm burden reduction (%)

T. muris

 Emodepside

75

100

100

10

62.0

85.9

2.5

60.9

69.6

1.25

5.3

73.9

 Albendazolea

600

49.4

20.2

 Levamisole-HCla

200

90.5

95.9

 Pyrantel pamoatea

300

9.4

0

A. ceylanicum

 Emodepside

2.5

100

100

 Albendazolea

1.25

70.5

87.8

2.5

100

100

5

100

100

 Levamisole-HCla

10

44.3

60.2

 Pyrantel pamoatea

10

63.4

87.2

N. americanus

 Emodepside

10

100

100

5

100

100

2.5

87.5

100

1.25

40.0

62.5

 Albendazolea

10

100

100

5

69.6

70.8

  1. aAll values for this drug are taken from the study of Tritten et al. [36]