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Table 4 In vivo dose response relationships of emodepside, albendazole, levamisole and pyrantel pamoate on A. ceylanicum, N. americanus and T. muris

From: Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections

Drug Dose (mg/kg) Worm expulsion rate (%) Worm burden reduction (%)
T. muris
 Emodepside 75 100 100
10 62.0 85.9
2.5 60.9 69.6
1.25 5.3 73.9
 Albendazolea 600 49.4 20.2
 Levamisole-HCla 200 90.5 95.9
 Pyrantel pamoatea 300 9.4 0
A. ceylanicum
 Emodepside 2.5 100 100
 Albendazolea 1.25 70.5 87.8
2.5 100 100
5 100 100
 Levamisole-HCla 10 44.3 60.2
 Pyrantel pamoatea 10 63.4 87.2
N. americanus
 Emodepside 10 100 100
5 100 100
2.5 87.5 100
1.25 40.0 62.5
 Albendazolea 10 100 100
5 69.6 70.8
  1. aAll values for this drug are taken from the study of Tritten et al. [36]