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Fig. 2 | Parasites & Vectors

Fig. 2

From: Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils

Fig. 2

Thoracic cavity cells of L. sigmodontis-infected IL-5−/−, dblGATA and IL-4R−/−/IL-5−/− mice lack eosinophils and IL-4R−/− and IL-4R−/−/IL-5−/− mice lack alternatively activated macrophages. Total number of thoracic cavity cells in IL-4R−/−, dblGATA, IL-5−/−, IL-4R−/−/IL-5−/− mice and wildtype (WT) controls at 71 (a) and 119 days (b) post-L. sigmodontis-infection. Total thoracic cavity macrophage numbers (c, d), RELMα positive alternatively activated macrophage (AAM, e, f) and eosinophil numbers (g, h) at 71 and 119 days post-L. sigmodontis-infection (ah), as well as expression of CD54 (i) and CD69 on eosinophils (j) at 71 days post-L. sigmodontis-infection and naïve WT controls (gj). Results are shown as medians. Data were analyzed using one-way ANOVA followed by Dunnett’s test (c, g) and Kruskal-Wallis followed by Dunn’s multiple comparison test (a, b, df, hj). *P < 0.05, **P < 0.01, ***P < 0.001. Data shown in a, c, e, g are pooled from two independent experiments at 71 dpi with 10–16 mice per group. Remaining panels (b, d, f, h) are from one experiment at 119 dpi with 6–10 mice per group. i, j Representative of one independent experiment at 71 dpi with 4–6 mice per group

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