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Fig. 4 | Parasites & Vectors

Fig. 4

From: Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL-33/ST2 expression

Fig. 4

Suppression of tTG activity by cystamine treatment diminishes the extent of hepatic fibrosis. tTG activity in mice was inhibited by cystamine (CTM) through daily intraperitoneal injection from day 3 to day 10 after Sj infection. Mice were sacrificed at week 6. Non-infected mice with or without CTM treatment served as controls. a Representative Sirius red staining (200×, scale-bar: 50 μm) of Sj single egg granuloma is shown on the left panel. The percentage of morphometric collagen areas of single Sj egg granuloma is displayed on the right panel (t-test, ****P < 0.0001, ***P = 0.0003). b The protein expression level of Col1 in mice liver homogenates detected by Western blotting is displayed on the left panel, and the result of semi-quantitative analysis is shown on the right panel. GAPDH was used as loading control. c The average Sj egg number present in each liver section is shown. Data are presented as the mean ± SD. All experiments were performed twice or thrice. Red arrows indicate the Sj eggs (t-test, *P = 0.0496)

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