Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1H NMR-based metabolomics study

Parasites & Vectors

Table 2 Post-hoc power analyses of characteristic metabolites with G*power

Metabolite	Control group	HAE group	t-value^b	P-value^c	ES^d	SP^e
Metabolite	CONC^a	CONC^a	t-value^b	P-value^c	ES^d	SP^e
1-methylhistidine	15.52 ± 0.56	12.6 ± 0.74	3.38	3.55 × 10⁻³	1.05	0.86
3-hydroxybutyrate	11.51 ± 0.36	13.30 ± 0.52	3.03	7.56 × 10⁻³	0.95	0.79
3-methylhistidine	48.17 ± 1.64	69.37 ± 7.16	3.09	6.70 × 10⁻³	0.96	0.80
Betaine	10.90 ± 0.62	6.68 ± 0.83	4.61	2.50 × 10⁻⁴	1.36	0.98
Creatine	52.02 ± 1.19	39.87 ± 2.13	5.89	1.78 × 10⁻⁵	1.66	1.00
Creatinine	1438.09 ± 45.22	1128.99 ± 61.68	4.54	2.87 × 10⁻⁴	1.35	0.98
Formate	1.31 ± 0.10	2.20 ± 0.24	3.72	1.69 × 10⁻³	1.14	0.91
Glutamate	11.39 ± 1.29	20.71 ± 1.37	5.82	2.05 × 10⁻⁵	1.65	1.00
Glutamine	2.96 ± 0.35	1.77 ± 0.24	3.78	1.48 × 10⁻³	0.93	0.78
Glycolate	36.33 ± 1.34	49.44 ± 4.30	3.11	6.32 × 10⁻³	0.97	0.81
Isoleucine	17.14 ± 0.63	13.08 ± 0.71	4.87	1.44 × 10⁻⁴	1.43	0.99
Lactate	102.96 ± 10.14	140.90 ± 9.54	2.89	1.01 × 10⁻²	0.91	0.75
Leucine	15.70 ± 0.56	11.79 ± 0.48	6.36	7.05 × 10⁻⁶	1.77	1.00
Lysine	4.33 ± 0.19	2.47 ± 0.35	5.40	4.80 × 10⁻⁵	1.55	0.99
Malate	18.06 ± 0.33	20.95 ± 0.73	3.97	9.94 × 10⁻⁴	1.20	0.94
Phenylalanine	6.67 ± 0.61	10.02 ± 0.57	5.98	1.48 × 10⁻⁵	1.14	0.91
p-hydroxyphenylacetate	2.57 ± 0.08	3.91 ± 0.34	4.27	5.13 × 10⁻⁴	1.28	0.96
Serine	11.19 ± 0.75	7.52 ± 0.70	3.93	1.09 × 10⁻³	1.19	0.93
Tyrosine	8.11 ± 0.33	9.98 ± 0.52	3.26	4.59 × 10⁻³	1.01	0.84
Valine	28.35 ± 1.23	19.90 ± 0.78	4.43	3.66 × 10⁻⁴	1.94	1.00
γ-aminobutyrate	29.29 ± 0.78	33.44 ± 1.08	3.35	3.80 × 10⁻³	1.04	0.68

^aThe relative concentration (percentage of normalized integrals, mean ± standard error)
^bThe calculated t-value in the Student’s t-test based on 17 degrees of freedom
^cThe calculated statistical significance in the Student’s t-test
^dThe calculated effect size with G*power
^eThe calculated statistical power calculated as a function of the critical significance level (α = 0.05), given sample size (n = 18), and obtained variable effect size in G*power

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