Table 3 Worm distribution in the hepatic and portomesenteric vessels of S. mansoni-infected treated mice

Control

21.00 ± 0.59

12.44 ± 1.6

8.56 ± 1.0

5.33 ± 1.14

15.66 ± 1.98

62.5

M-PZQ

10.17 ± 0.4

(51.59)*

6.33 ± 1.0

(49.09)*

3.83 ± 0.7

(55.22)*

4.66 ± 0.8

5.5 ± 0.62*

SLN-PZQ

2.83 ± 0.7

(86.51)*^†

2.67 ± 0.7

(78.56)*^†

0.17 ± 0.1

(98.05)*^†

1.00 ± 0.26*^†

1.83 ± 0.60*^†

125

M-PZQ

5.83 ± 0.7

(72.22)*

3.83 ± 1.0

(69.19)*

1.33 ± 0.2

(84.42)*

2.83 ± 0.98*

2.33 ± 0.76*

SLN-PZQ

1.17 ± 0.4

(94.44)*^†

0.83 ± 0.3

(92.50)*^†

0.33 ± 0.2

(95.33)*^†

0.33 ± 0.21*^$

0.83 ± 0.98*

250

M-PZQ

2.29 ± 0.1

(89.10)*

2.0 ± 0.2

(83.92)*

0.29 ± 0.1

(96.66)*

0.57 ± 0.4*

0.57 ± 0.20*

SLN-PZQ

0.83 ± 0.3

(96.05)*^†

0.67 ± 0.2

(94.64)*

0.17 ± 0.1

(98.05)*

0.33 ± 0.5*

0.33 ± 0.20*

500

M-PZQ

1.43 ± 0.2

(93.19)*

0.86 ± 0.3

(93.11)*

0.57 ± 0.2

(93.32)*

1.17 ± 0.38*

0.29 ± 0.49*

SLN-PZQ

0.50 ± 0.3

(97.62)*

0.33 ± 0.3

(97.32)*

0.33 ± 0.2

(98.05)*

0.5 ± 0.34*

0.00 ± 0.00*

1000

M-PZQ

0.75 ± 0.3

(96.43)*

0.63 ± 0.3

(94.98)*

0.13 ± 0.1

(98.54)*

0.75 ± 0.31*

0.00 ± 0.00*

SLN-PZQ

0.33 ± 0.2

(98.43)*

0.33 ± 0.2

(97.32)*

0.00 ± 0.0

(100.0)*

0.17 ± 0.16*

0.16 ± 0.16*