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Table 1 KEGG enrichment analysis of the up- and downregulated genes in the La-SbIII-R line

From: Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate

Pathway ID

Map name

Genes

Upregulated genes

 ec00240

Pyrimidine metabolism

LmxM.13.1630, LmxM.18.1580, LmxM.21.1210, LmxM.23.0680, LmxM.28.0890, LmxM.28.1420, LmxM.28.1430, LmxM.33.0010, LmxM.34.1790

Downregulated genes

 ec00130

Ubiquinone and other terpenoid-quinone biosynthesis

LmxM.05.1100, LmxM.34.0500, LmxM.34.0500a, LmxM.34.0520b, LmxM.34.0540, LmxM.34.0550

 ec00260

Glycine, serine and threonine metabolism

LmxM.10.0090, LmxM.14.1320, LmxM.29.2090, LmxM.32.0520, LmxM.36.3800

 ec00053

Ascorbate and aldarate metabolism

LmxM.10.0090, LmxM.18.0160, LmxM.26.0160, LmxM.32.0520, LmxM.33.0010, LmxM.34.0500, LmxM.34.0500a, LmxM.34.0520b, LmxM.34.0540, LmxM.34.0550

 ec00670

One carbon pool by folate

LmxM.14.1320, LmxM.36.3800, LmxM.36.6390

 ec00980

Metabolism of xenobiotics by cytochrome P450

LmxM.29.2090, LmxM.32.0240

 ec00982

Drug metabolism - cytochrome P450

LmxM.29.2090, LmxM.32.0240

 ec00531

Glycosaminoglycan degradation

LmxM.34.0500, LmxM.34.0500a, LmxM.34.0520b, LmxM.34.0540, LmxM.34.0550