Table 2 List of most highly differentially-expressed genes between the La-SbIII-S and La-SbIII-R lines (P-value cut-off < 0.05 and fold-change difference ≥ 2)
Biological functions | Transcript | Product description | Log2 fold-change (R/S) |
|---|---|---|---|
Surface proteins | LmxM.09.0580 | Surface antigen-like protein | − 1.1603 |
LmxM.05.1215 | Surface antigen-like protein | − 1.2685 | |
LmxM.21.1170 | Surface antigen-like protein | − 1.2882 | |
LmxM.04.0190 | Surface antigen-like protein | − 1.8081 | |
LmxM.04.0210 | Surface antigen-like protein | − 1.9894 | |
LmxM.04.0180 | Surface antigen-like protein | − 2.0656 | |
LmxM.04.0200 | Surface antigen-like protein | − 2.3355 | |
LmxM.05.0900 | Surface antigen-like protein | − 3.7896 | |
LmxM.34.0550 | Proteophosphoglycan ppg1 | − 1.5215 | |
LmxM.34.0500 | Proteophosphoglycan ppg3, putative | − 3.2111 | |
LmxM.33.3120 | Lipophosphoglycan biosynthetic protein (lpg2) | − 1.2312 | |
LmxM.30.1450 | Surface membrane protein gp46-like protein | − 1.3431 | |
LmxM.28.0570 | Major surface protease gp63, putative | − 3.0596 | |
LmxM.08.0730 | Amastin-like protein, putative | 1.0151 | |
LmxM.28.1400 | Amastin-like protein | 1.1033 | |
LmxM.08.0720 | Amastin-like protein, putative | 1.1165 | |
LmxM.08.0740 | Amastin-like protein, putative | 1.2047 | |
LmxM.33.1920 | Amastin-like surface protein, putative | 1.7594 | |
Metabolism | Metabolite transporters | ||
LmxM.10.0350 | Pteridine transporter ft5, putative | − 1.0251 | |
LmxM.24.0360 | UDP-galactose transporter | − 1.0742 | |
LmxM.15.1230 | Nucleoside transporter 1, putative | − 1.4466 | |
LmxM.32.0290 | Glucose transporter/membrane transporter D2, putative | − 1.5513 | |
LmxM.15.1240 | Nucleoside transporter 1, putative | − 1.9139 | |
LmxM.30.0320 | Amino acid transporter, putative | − 1.9548 | |
Glycolysis | |||
LmxM.10.0510 | Glycerol-3-phosphate dehydrogenase [NAD+], glycosomal/mitochondrial | − 1.1530 | |
Proteolysis | |||
LmxM.08.1080 | Cathepsin L-like protease, putative | − 2.2280 | |
Fatty acid pathways | |||
LmxM.30.2970 | Acetyl-CoA carboxylase | 1.0198 | |
LmxM.23.0710 | Acetyl-CoA synthetase, putative | 1.3180 | |
Other metabolic enzymes | |||
LmxM.29.1940 | Succinyl-coa:3-ketoacid-coenzyme a transferase- like protein | − 1.5541 | |
LmxM.26.1610 | Proline dehydrogenase, mitochondrial | 1.2112 | |
LmxM.27.0880 | 2-oxoglutarate dehydrogenase subunit, putative | 1.1954 | |
Cell cycle | LmxM.20.0030 | Histone-lysine N-methyltransferase, H3 lysine-76 specific | 2.4946 |
LmxM.07.0025 | Histone-lysine N-methyltransferase, putative | 2.4788 | |
LmxM.10.0990 | Histone H3 | 2.0457 | |
LmxM.10.0870 | Histone H3 | 1.8415 | |
LmxM.25.0920 | Histone RNA hairpin-binding protein | 1.5715 | |
LmxM.20.0050 | Histone chaperone ASF1A | 1.3835 | |
LmxM.36.0020 | Histone H4 | 1.2945 | |
LmxM.19.0050 | Histone H2B | 1.2791 | |
LmxM.30.3180 | Histone H4 | 1.1477 | |
LmxM.34.1310 | Histone H4 | 1.0938 | |
LmxM.19.0030 | Histone H2B | 1.0316 | |
LmxM.25.1470 | Cyclin | 2.3643 | |
LmxM.31.3320 | Cyclin 6, putative | 1.2431 | |
LmxM.28.1420 | DNA polymerase kappa, putative | 1.2764 | |
LmxM.28.1430 | DNA polymerase kappa, putative | 1.2214 | |
LmxM.34.1790 | DNA polymerase epsilon subunit B, putative | 1.1082 | |
LmxM.13.1630 | Mitochondrial DNA polymerase I protein D, putative | 1.0411 | |
Autophagy | LmxM.27.0390 | Autophagy protein APG9, putative | 1.2217 |
LmxM.23.1170 | Membrane-bound acid phosphatase 2 | 1.5534 | |
Cytoskeletal | LmxM.08.1230 | β-tubulin | − 1.1278 |
LmxM.21.1860 | β-tubulin | − 1.8051 | |
LmxM.32.0792 | β-tubulin | − 1.9300 | |
LmxM.05.0040 | Paraflagellar rod component par4, putative | − 1.2326 | |
LmxM.16.1430 | Paraflagellar rod protein 2 | − 1.2388 | |
LmxM.09.1320 | Paraflagellar rod component, putative | − 1.3933 | |
LmxM.08_29.1750 | Paraflagellar rod protein 1D, putative | − 1.3995 | |
LmxM.36.4780 | Paraflagellar rod component, putative | − 1.6234 | |
LmxM.16.1425 | Paraflagellar rod protein 2C | − 1.9274 | |
LmxM.08_29.1760 | Paraflagellar rod protein 1D, putative | − 1.9294 | |
LmxM.07.0310 | Paraflagellar rod protein, putative | − 2.0882 | |
LmxM.32.0610 | Paraflagellar rod component, putative | − 2.3516 | |
LmxM.36.4230 | Paraflagellar rod component, putative | − 3.0082 | |
Transporters associated with antimony response | LmxM.28.1930 | Zinc transporter 3, putative | 1.5220 |
LmxM.30.3070 | Ferrous iron transport protein | 1.1716 | |
LmxM.23.0250 | ABC-thiol transporter | 1.1165 | |
LmxM.19.0180 | Mitogen-activated protein kinase 9, putative | 1.0732 | |
LmxM.13.0440 | Mitogen-activated protein kinase kinase 2 | 1.0641 | |
LmxM.30.1290 | Multidrug-resistance protein, copy 1-like protein | 1.1374 | |
H-locus | LmxM.23.0230 | Hypothetical protein, conserved | 1.0664 |
LmxM.23.0240 | Terbinafine resistance locus protein (yip1) | 1.3429 | |
LmxM.23.0250 | ABC-thiol transporter | 1.1165 | |
LmxM.23.0260 | Argininosuccinate synthase, putative | 1.2138 | |
Chaperones and stress proteins | LmxM.36.2030 | Chaperonin HSP60, mitochondrial precursor | 1.1311 |
LmxM.28.2780 | Heat-shock protein hsp70, putative | 2.6066 | |
LmxM.32.0312 | Heat-shock protein 83-1 | 2.3109 | |
LmxM.32.0316 | Heat-shock protein 83-1 | 2.1008 | |
LmxM.32.0314 | Heat-shock protein 83-1 | 2.0412 | |
LmxM.18.1370 | Heat-shock protein, putative | 1.3501 | |
LmxM.28.2770 | Heat-shock protein hsp70, putative | 1.1175 | |