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Table 2 List of most highly differentially-expressed genes between the La-SbIII-S and La-SbIII-R lines (P-value cut-off < 0.05 and fold-change difference ≥ 2)

From: Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate

Biological functions Transcript Product description Log2 fold-change (R/S)
Surface proteins LmxM.09.0580 Surface antigen-like protein − 1.1603
LmxM.05.1215 Surface antigen-like protein − 1.2685
LmxM.21.1170 Surface antigen-like protein − 1.2882
LmxM.04.0190 Surface antigen-like protein − 1.8081
LmxM.04.0210 Surface antigen-like protein − 1.9894
LmxM.04.0180 Surface antigen-like protein − 2.0656
LmxM.04.0200 Surface antigen-like protein − 2.3355
LmxM.05.0900 Surface antigen-like protein − 3.7896
LmxM.34.0550 Proteophosphoglycan ppg1 − 1.5215
LmxM.34.0500 Proteophosphoglycan ppg3, putative − 3.2111
LmxM.33.3120 Lipophosphoglycan biosynthetic protein (lpg2) − 1.2312
LmxM.30.1450 Surface membrane protein gp46-like protein − 1.3431
LmxM.28.0570 Major surface protease gp63, putative − 3.0596
LmxM.08.0730 Amastin-like protein, putative 1.0151
LmxM.28.1400 Amastin-like protein 1.1033
LmxM.08.0720 Amastin-like protein, putative 1.1165
LmxM.08.0740 Amastin-like protein, putative 1.2047
LmxM.33.1920 Amastin-like surface protein, putative 1.7594
Metabolism Metabolite transporters
LmxM.10.0350 Pteridine transporter ft5, putative − 1.0251
LmxM.24.0360 UDP-galactose transporter − 1.0742
LmxM.15.1230 Nucleoside transporter 1, putative − 1.4466
LmxM.32.0290 Glucose transporter/membrane transporter D2, putative − 1.5513
LmxM.15.1240 Nucleoside transporter 1, putative − 1.9139
LmxM.30.0320 Amino acid transporter, putative − 1.9548
Glycolysis
LmxM.10.0510 Glycerol-3-phosphate dehydrogenase [NAD+], glycosomal/mitochondrial − 1.1530
Proteolysis
LmxM.08.1080 Cathepsin L-like protease, putative − 2.2280
Fatty acid pathways
LmxM.30.2970 Acetyl-CoA carboxylase 1.0198
LmxM.23.0710 Acetyl-CoA synthetase, putative 1.3180
Other metabolic enzymes
LmxM.29.1940 Succinyl-coa:3-ketoacid-coenzyme a transferase- like protein − 1.5541
LmxM.26.1610 Proline dehydrogenase, mitochondrial 1.2112
LmxM.27.0880 2-oxoglutarate dehydrogenase subunit, putative 1.1954
Cell cycle LmxM.20.0030 Histone-lysine N-methyltransferase, H3 lysine-76 specific 2.4946
LmxM.07.0025 Histone-lysine N-methyltransferase, putative 2.4788
LmxM.10.0990 Histone H3 2.0457
LmxM.10.0870 Histone H3 1.8415
LmxM.25.0920 Histone RNA hairpin-binding protein 1.5715
LmxM.20.0050 Histone chaperone ASF1A 1.3835
LmxM.36.0020 Histone H4 1.2945
LmxM.19.0050 Histone H2B 1.2791
LmxM.30.3180 Histone H4 1.1477
LmxM.34.1310 Histone H4 1.0938
LmxM.19.0030 Histone H2B 1.0316
LmxM.25.1470 Cyclin 2.3643
LmxM.31.3320 Cyclin 6, putative 1.2431
LmxM.28.1420 DNA polymerase kappa, putative 1.2764
LmxM.28.1430 DNA polymerase kappa, putative 1.2214
LmxM.34.1790 DNA polymerase epsilon subunit B, putative 1.1082
LmxM.13.1630 Mitochondrial DNA polymerase I protein D, putative 1.0411
Autophagy LmxM.27.0390 Autophagy protein APG9, putative 1.2217
LmxM.23.1170 Membrane-bound acid phosphatase 2 1.5534
Cytoskeletal LmxM.08.1230 β-tubulin − 1.1278
LmxM.21.1860 β-tubulin − 1.8051
LmxM.32.0792 β-tubulin − 1.9300
LmxM.05.0040 Paraflagellar rod component par4, putative − 1.2326
LmxM.16.1430 Paraflagellar rod protein 2 − 1.2388
LmxM.09.1320 Paraflagellar rod component, putative − 1.3933
LmxM.08_29.1750 Paraflagellar rod protein 1D, putative − 1.3995
LmxM.36.4780 Paraflagellar rod component, putative − 1.6234
LmxM.16.1425 Paraflagellar rod protein 2C − 1.9274
LmxM.08_29.1760 Paraflagellar rod protein 1D, putative − 1.9294
LmxM.07.0310 Paraflagellar rod protein, putative − 2.0882
LmxM.32.0610 Paraflagellar rod component, putative − 2.3516
LmxM.36.4230 Paraflagellar rod component, putative − 3.0082
Transporters associated with antimony response LmxM.28.1930 Zinc transporter 3, putative 1.5220
LmxM.30.3070 Ferrous iron transport protein 1.1716
LmxM.23.0250 ABC-thiol transporter 1.1165
LmxM.19.0180 Mitogen-activated protein kinase 9, putative 1.0732
LmxM.13.0440 Mitogen-activated protein kinase kinase 2 1.0641
LmxM.30.1290 Multidrug-resistance protein, copy 1-like protein 1.1374
H-locus LmxM.23.0230 Hypothetical protein, conserved 1.0664
LmxM.23.0240 Terbinafine resistance locus protein (yip1) 1.3429
LmxM.23.0250 ABC-thiol transporter 1.1165
LmxM.23.0260 Argininosuccinate synthase, putative 1.2138
Chaperones and stress proteins LmxM.36.2030 Chaperonin HSP60, mitochondrial precursor 1.1311
LmxM.28.2780 Heat-shock protein hsp70, putative 2.6066
LmxM.32.0312 Heat-shock protein 83-1 2.3109
LmxM.32.0316 Heat-shock protein 83-1 2.1008
LmxM.32.0314 Heat-shock protein 83-1 2.0412
LmxM.18.1370 Heat-shock protein, putative 1.3501
LmxM.28.2770 Heat-shock protein hsp70, putative 1.1175