Clinical aspects of visceral leishmaniasis caused by L. infantum in adults. Ten years of experience of the largest outbreak in Europe: what have we learned?

Table 4 HLH criteria assessed

	IC-VL (n = 84)	HIV-VL (n = 11)	IS-VL (n = 16)	Total (n = 111)	P-value
Fever (%)	98	73	94	95	χ² = 11.81, df = 2, P = 0.003*
Radiological splenomegaly (%)	95	91	87	93	0.472
Cytopenia (at least 2 blood cell lines) (%)	94	91	94	94	0.930
Hypertriglyceridemia (> 265 mg/dl) (%)	23	9	25	22	0.552
Hemophagocytosis in bone marrow (%)	50	22	75	52	χ² = 6.69, df = 2, P = 0.035*
Ferritin > 500 mg/l (%)	86	78	93	86	0.551

Abbreviations: n, sample size for each group; IC-VL, visceral leishmaniasis in immunocompetent patients; HIV-VL, visceral leishmaniasis in patients with HIV; IS-VL, visceral leishmaniasis in immunosuppressed patients (receiving steroids, methotrexate, anti-TNF)
*P < 0.05

ISSN: 1756-3305