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Table 4 HLH criteria assessed

From: Clinical aspects of visceral leishmaniasis caused by L. infantum in adults. Ten years of experience of the largest outbreak in Europe: what have we learned?

 IC-VL (n = 84)HIV-VL (n = 11)IS-VL (n = 16)Total (n = 111)P-value
Fever (%)98739495χ2 = 11.81, df = 2, P = 0.003*
Radiological splenomegaly (%)959187930.472
Cytopenia (at least 2 blood cell lines) (%)949194940.930
Hypertriglyceridemia (> 265 mg/dl) (%)23925220.552
Hemophagocytosis in bone marrow (%)50227552χ2 = 6.69, df = 2, P = 0.035*
Ferritin > 500 mg/l (%)867893860.551
  1. Abbreviations: n, sample size for each group; IC-VL, visceral leishmaniasis in immunocompetent patients; HIV-VL, visceral leishmaniasis in patients with HIV; IS-VL, visceral leishmaniasis in immunosuppressed patients (receiving steroids, methotrexate, anti-TNF)
  2. *P < 0.05