Table 2 Top most downregulated genes in the Culex quinquefasciatus larvae from the RIAB59 resistant colony, revealed by the RNA-seq analysis
Gene_id | Description | Log2 fold change | P-value |
|---|---|---|---|
CPIJ017593/CPIJ017592 | Vanin 1-pantetheinase precursor | 7.13 | 1.51E−49 |
CPIJ001035 | Lipase member H | 5.43 | 2.23E−45 |
CPIJ016846 | Cytochrome P450 paralogue | 5.14 | 1.11E−23 |
CPIJ013173 | Cqm1-Maltase 2 | 4.65 | 9.14E−304 |
CPIJ011081/CPIJ011083 | Heat-shock 70 B2 | 4.58 | 1.90E−13 |
CPIJ002679 | Glutathione S-transferase theta-2 | 4.57 | 2.83E−16 |
CPIJ018744 | Ankyrin-2,3 | 4.44 | 8.08E−16 |
CPIJ006512 | Hypothetical protein | 4.35 | 1.10E−13 |
CPIJ014435 | Cuticle protein 38-like | 4.33 | 2.85E−16 |
CPIJ009045 | Fatty acid hydroxylase superfamily | 4.19 | 1.67E−39 |
CPIJ015726/CPIJ015727 | Apolipoprotein D, putative | 4.10 | 6.54E−13 |
CPIJ005154 | Nuclear transport factor 2 | 4.06 | 4.14E−15 |
CPIJ002783 | AN1-type zinc finger 2B | 3.97 | 2.52E−12 |
CPIJ014193 | Chitin-binding protein | 3.95 | 2.18E−51 |
CPIJ008858 | STRK3/rubber oxygenase | 3.94 | 6.51E−29 |
CPIJ004068 | UBASH3A homolog | 3.88 | 8.78E−13 |
CPIJ011433 | Chymotrypsin BI | 3.77 | 2.73E−35 |
CPIJ017634 | Apoptosis-inducing factor mitochondrial | 3.75 | 7.73E−10 |
CPIJ007305 | Conserved hypothetical protein | 3.72 | 1.61E−10 |
CPIJ018624 | Glutathione S-transferase 1 | 3.64 | 4.20E−25 |
CPIJ005645 | Heat-shock protein 22 | 3.63 | 1.38E−08 |
CPIJ003813 | Pickpocket (chemoreceptor) | 3.57 | 1.39E−10 |
CPIJ008659 | Metalloproteinase putative | 3.53 | 4.00E−12 |
CPIJ002726 | Lipase 3 precursor | 3.52 | 8.39E−18 |
CPIJ014889 | Pyruvate dehydrogenase | 3.47 | 3.65E−09 |
CPIJ016451 | Crotonobetainyl-CoA dehydrogenase | 3.40 | 1.37E−101 |
CPIJ008888 | p53 and DNA damage-regulated 1 | 3.37 | 1.15E−28 |
CPIJ004369 | UDP-glucuronosyltransferase 1–7C | 3.31 | 3.74E−12 |
CPIJ014496 | Transient receptor potential cation channel protein | 3.30 | 1.33E−15 |
CPIJ004637 | Glutactin | 3.22 | 6.40E−67 |
CPIJ013192 | Hypothetical protein | 3.20 | 9.53E−08 |
CPIJ015075/CPIJ011244 | Heat-shock protein 83 | 3.16 | 4.56E−17 |
CPIJ018427 | Nuclear pore complex Nup93-1 | 3.14 | 6.45E−07 |
CPIJ017588 | Peroxidase | 3.13 | 5.69E−08 |
CPIJ011585 | Glutamate–cysteine ligase | 3.12 | 5.48E−12 |
CPIJ019704 | Probable cytochrome P450 6a17 | 3.12 | 8.99E−09 |
CPIJ019567 | Vegetatible incompatibility protein HET-E-1 | 3.08 | 3.22E−07 |
CPIJ002042 | Translocon-associated protein subunit delta | 3.04 | 5.36E−07 |