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Table 7 Field trials of commercial products of Bacillus thuringiensis var. israelensis and Bacillus sphaericus against adult malaria vectors and the effect on malaria transmission in sub-Saharan Africa

From: Bacterial larvicides used for malaria vector control in sub-Saharan Africa: review of their effectiveness and operational feasibility

Country

Vectors targeted

Product (application rate)

Application cycle

Percentage reduction

References

Adult density/biting

Transmission/EIR

Malaria prevalence

Mbita, Kenya

An. gambiae (s.l.); An. funestus

VectoBac® WDG (0.2 kg/ha); VectoBac® CG (5.0 kg/ha); VectoLex® WDG (1.0 kg/ha) and VectoLex® CG (15.0 kg/ha)

1/2 weeke

92.0a

–

–

[49]

Dar es Salaam, Tanzania

An. gambiae (s.l.)

VectoBac® WDG (0.4 kg/ha); VectoBac® CG (10.0 kg/ha); VectoLex® WDG (2.0 kg/ha); VectoLex® CG (30.0 kg/ha)

1 week

31.3a

71c

40.0

[60]

  

VectoBac® (Not stated); Bactivec® (not stated)

–

Reducedb

–

Reduced

[91]

Kakamega and Vihiga, Kenya

An. gambiae (s.l.); An. funestus

VectoBac® WDG; VectoBac® CG; VectoLex® WDG; VectoLex® CG

1 week

85.9b

73.1d

–

[10]

Dar es Salaam, Tanzania

An. gambiae (s.l.); An. funestus; An. coustani

VectoBac® WDG (0.4 kg/ha); VectoBac® CG (10.0 kg/ha)

1 week

72.0b

32.0d

Reduced

[32]

Kinshasa, Zaireg

An. gambiae (s.l.)

VectoLex® G (10.0 kg/ha)

2 weeks

13.6a

39.9d,f

–

[51]

Western, Kenya

An. gambiae (s.l.); An. funestus

FourStar® Briquettes (1 briq/100 ft2)

Once

60.0–85.0b

–

–

[47]

Nouna, Burkina Faso

An. gambiae (s.l.); An. funestus

VectoBac® WDG (not stated)

10 days

72–80b

–

–

[61]

Bobirwa, Botswana

An. arabiensis

VectoBac® 12 AS (2.0 l/ha); VectoBac® G (2.0 g/m2)

Once

Reducedb

Reducedc

Decreased

[81]

Eritrea

An. arabiensis

VectoBac® G (11.2 kg/ha); VectoLex® CG (22.4 kg/ha)

1 week

Significantly reducedb

–

–

[89]

Tiémélékro, Côte d’Ivoire

An. gambiae (s.l.); An. funestus (s.l.)

VectoBac® (0.8 mg/l); VectoLex® (10 mg/l)

3 weeks

Significantly reduceda

Significantly reducedd

–

[85]

Maroua, Cameroon

An. gambiae (s.l.); An. funestus;

Bs strain 2362 (10 g/m2)

3 rounds

Reduceda

Reducedc

–

[18]

Cotonou, Benin

Anopheles

Bti (50 mg/l)

2 weeks

Reduceda

–

Reduced

[22]

Gambia

An. gambiae (s.l.)

VectoBac® WDG (0.2 kg/ha); VectoBac® CG (5.0 kg/ha)

1 week

Limitedb

Unsatisfactoryc

No effect

[50]

  1. Reported percentage reductions are based on: ahuman biting; badult density; cmalaria transmission; and dEIR
  2. e1 week for Vectobac® and 2 weeks for Vectolex®
  3. fEstimated from reduction in EIR from 0.238 to 0.143
  4. gZaire: now The Democratic Republic of the Congo
  5. Notes: Tested product (potency): VectoBac® WDG (3000 ITU/mg); Vectobac® CG (200 ITU/mg); VectoLex® WDG (650 ITU/mg); Vectolex® CG (50 ITU/mg); VectoLex® G (200 ITU/mg)
  6. Abbreviations: briq, briquettes; CG, corn granules; G, granules; ITU, international toxic units; WDG, water-dispersible granules; EIR, entomological inoculation rate