Table 2 Potential biomarker metabolites of Toxocara canis infection in dog serum at 12 hpi and 24 hpi to 36 dpi by LC-MS/MS
From: Serum metabolomic alterations in Beagle dogs experimentally infected with Toxocara canis
Infection stage | Ion mode | Metabolites | Entry | AUC | P-value | Log2(FC) | Metabolic pathways |
|---|---|---|---|---|---|---|---|
12 hpi | ESI(+) | O-isovaleryl-l-carnitine | C20826 | 0.959 | 0.0158 | − 0.4179 | Not known |
12 hpi | ESI(+) | TG(i-16:0/i-16:0/13:0) | HMDB0103789 | 0.959 | 0.0056 | 0.5935 | Not known |
12 hpi | ESI(+) | (2E)-3-[4-(sulfooxy)phenyl]prop-2-enoic acid | HMDB0125166 | 0.939 | 0.0057 | − 1.0655 | Not known |
12 hpi | ESI(+) | 3’-deoxydihydrostreptomycin | C03755 | 0.939 | 0.0027 | 0.3250 | Not known |
12 hpi | ESI(+) | Docosahexaenoic acid | C06429 | 0.918 | 0.0142 | − 0.4043 | Biosynthesis of unsaturated fatty acids |
12 hpi | ESI(+) | Novapikromyin | C20740 | 0.918 | 0.0094 | 0.2805 | Not known |
12 hpi | ESI(−) | Calcitroic acid | C18230 | 1.000 | 0.0487 | − 0.4470 | Not known |
12 hpi | ESI(−) | Docosapentaenoic acid | C16513 | 0.959 | 0.0081 | − 0.4776 | Biosynthesis of unsaturated fatty acids |
12 hpi | ESI(−) | Monoacylglycerol | HMDB0011573 | 0.918 | 0.0086 | − 0.4091 | Not known |
24 hpi to 36 dpi | ESI(+) | Biotin amide | C01893 | 0.871 | 2.21E−05 | 0.8046 | Not known |
24 hpi to 36 dpi | ESI(+) | Iridotrial | C06070 | 0.819 | 0.0067 | 0.3800 | Biosynthesis of secondary metabolites |
24 hpi to 36 dpi | ESI(+) | {[1-(4-methoxyphenyl)pentan-3-yl]oxy}sulfonic acid | HMDB0133010 | 0.807 | 0.0010 | 0.4903 | Not known |
24 hpi to 36 dpi | ESI(−) | Angiotensin (5–8) | C20972 | 0.810 | 0.0008 | − 0.3484 | Not known |
24 hpi to 36 dpi | ESI(−) | l-Threonate | L-Threonate | 0.807 | 0.0025 | 0.3041 | Ascorbate and aldarate metabolism |