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Table 4 Effect of the vaccination with a multiantigenic formulation containing candidate antigens OeTSP1, OeTSP2, OeRPP0, OePK4 and OeSEL in Montanide ISA 50 V2 on O. erraticus and O. moubata ticks fed on control and vaccinated rabbits

From: In silico selection of functionally important proteins from the mialome of Ornithodoros erraticus ticks and assessment of their protective efficacy as vaccine targets

Parameter Developmental stage Ornithodoros erraticus Ornithodoros moubata
Control Vaccinated (% reduction) Control Vaccinated (% reduction)
Ingested blood (mg) Males 3.1 ± 0.3 3.2 ± 0.1 26.2 ± 2.2 26.9 ± 2.1
Females 9.2 ± 0.8 9.3 ± 1.1 191.4 ± 57.1 180.1 ± 12.9 (5.9)
Nymphs-3 2.1 ± 0.2 2.0 ± 0.2 (4.8) 5.5 ± 0.7 5.3 ± 0.6 (3.6)
Mortality (%) Males 2.8 ± 5.3 2.2 ± 3.2 6.1 ± 2.6 14.1 ± 3.2 (8.0)
Females 1.1 ± 2.7 0 ± 0 9.0 ± 5.6 8.9 ± 8.4
Nymphs-3 0.4 ± 1.0 13.2 ± 7 (12.8)** 2.8 ± 2.2 3.3 ± 1.0 (0.5)
Moulting (%) Nymphs-3 62.3 ± 10.7 61.8 ± 9.0 96.8 ± 1.9 94.4 ± 4.8
Oviposition (no. eggs/female) Females 62.2 ± 7.3 26.6 ± 3.3 (57.0)** 200.0 ± 21.0 146.0 ± 12.9 (27.0)**
Fertility (no. nymphs/female) Females 54.1 ± 5.8 21.5 ± 2.7 (60.2)** 182.0 ± 23.0 137.5 ± 11.0 (24.5)**
Efficacy (%)    66.3   25.6
  1. Notes: Results are shown as the mean ± standard deviation for each rabbit group. Means were compared between ticks fed on vaccinated and control rabbits by one-way ANOVA followed by the Dunnett’s t-test. In parentheses, % of change in the corresponding parameter respect to the control: percentage of reduction for ingested blood, moulting, oviposition and fertility
  2. ** P < 0.01