Fig. 2
From: Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins
Activity of avermectins against Plasmodium mosquito stages in vitro. a Schematics of the progress of the parasite culturing process, highlighting the different schedules of compound treatment employed. b Assessment of compound effects on ookinete formation, expressed as the percentage of inhibition of P. berghei ookinete formation. c In vitro activity of selected compounds against oocyst formation. d In vitro activity of selected compounds on oocyst development. A total of 6 compounds were screened at a concentration of 10 μM: Iv; Do, Ep, Mo, Ab and Em. Bars correspond to RLU measurements represented as the percentage of RLU of the DMSO control. Results are expressed as the mean + SD. ****P < 0.0001, ***P < 0.001, **P < 0.01. Abbreviations: Iv, ivermectin; Do, doramectin; Ep, eprinomectin; Mo, moxidectin; Ab, abamectin; Em, emamectin