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Table 1 IC50 of avermectins against oocyst formation and maturation in vitro

From: Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins

Compound

Day0–Day3 (µM)

Day3–Day15 (µM)

IC50

SD

IC50

SD

Eprinomectin

5.70

2.31

4.59

2.26

Doramectin

7.08

1.91

4.32

1.76

Emamectin

7.31

2.45

7.36

1.50

Abamectin

8.77

4.38

7.93

4.14

Moxidectin

10.85

8.56

5.49

1.00

Ivermectin

11.58

0.44

9.32

1.64

  1. Notes: Compound concentration resulting in 50% inhibition (IC50) for oocyst growth and maturation were calculated for Ep, Do, Em, Ab, Mo, and Iv (assayed at 0.05, 0.5, 1, 5, 10, 25 and 50 µM). Results are expressed as the mean ± SD
  2. Abbreviations: Ep, eprinomectin; Do, doramectin; Em, emamectin; Ab, abamectin; Mo, moxidectin; Iv, ivermectin
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Parasites & Vectors

ISSN: 1756-3305

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