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Table 1 IC50 of avermectins against oocyst formation and maturation in vitro

From: Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins

CompoundDay0–Day3 (µM)Day3–Day15 (µM)
IC50SDIC50SD
Eprinomectin5.702.314.592.26
Doramectin7.081.914.321.76
Emamectin7.312.457.361.50
Abamectin8.774.387.934.14
Moxidectin10.858.565.491.00
Ivermectin11.580.449.321.64
  1. Notes: Compound concentration resulting in 50% inhibition (IC50) for oocyst growth and maturation were calculated for Ep, Do, Em, Ab, Mo, and Iv (assayed at 0.05, 0.5, 1, 5, 10, 25 and 50 µM). Results are expressed as the mean ± SD
  2. Abbreviations: Ep, eprinomectin; Do, doramectin; Em, emamectin; Ab, abamectin; Mo, moxidectin; Iv, ivermectin