The role of microRNAs in the pathogenesis, grading and treatment of hepatic fibrosis in schistosomiasis

Parasites & Vectors

Table 1 The role and underlying regulatory mechanisms of miRNAs in the pathogenesis of hepatic fibrosis in schistosomiasis

Function	Type	Target	Mechanism/pathway	References
Pro-fibrosis	miR-21, miR-96	Smad7	SMAD signaling pathway	[40, 41]
	miR-351	VDR	SMAD and IFN-γ signaling pathway	[45]
	miR-146a/b	STAT1	Regulates the transformation of macrophages from M1 to M2/IFN-γ signaling pathway	[46]
	miR-27b	PPARγ	Enhances the activation of hepatic stellate cells	[89]
Anti-fibrosis	miR-203-3p	IL-33/Smad3	IL-33/IL-13 pathway	[67, 70]
	let-7b	TβRI	TGF-β/SMAD signaling pathway	[80]
	miR-182	unknown	Preserves Tregs stability and suppressor function	[88]
	miR-15b, miR-16	Bcl2	Caspase signaling pathway	[90]
	miR-454	Smad4	SMAD signaling pathway	[91]
	miR-155	FOXO3a	ERK1 signaling pathway, EMT process	[92, 93]
	miR-29b-3p	COL1A1, COL3A1	TGF-β signaling pathway	[94]
	miR-92a-2-5p	TLR2	Promotes NIH-3T3 cell apoptosis	[95]

ISSN: 1756-3305