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Table 1 The role and underlying regulatory mechanisms of miRNAs in the pathogenesis of hepatic fibrosis in schistosomiasis

From: The role of microRNAs in the pathogenesis, grading and treatment of hepatic fibrosis in schistosomiasis

FunctionTypeTargetMechanism/pathwayReferences
Pro-fibrosismiR-21, miR-96Smad7SMAD signaling pathway[40, 41]
miR-351VDRSMAD and IFN-γ signaling pathway[45]
miR-146a/bSTAT1Regulates the transformation of macrophages from M1 to M2/IFN-γ signaling pathway[46]
miR-27bPPARγEnhances the activation of hepatic stellate cells[89]
Anti-fibrosismiR-203-3pIL-33/Smad3IL-33/IL-13 pathway[67, 70]
let-7bTβRITGF-β/SMAD signaling pathway[80]
miR-182unknownPreserves Tregs stability and suppressor function[88]
miR-15b, miR-16Bcl2Caspase signaling pathway[90]
miR-454Smad4SMAD signaling pathway[91]
miR-155FOXO3aERK1 signaling pathway, EMT process[92, 93]
miR-29b-3pCOL1A1, COL3A1TGF-β signaling pathway[94]
miR-92a-2-5pTLR2Promotes NIH-3T3 cell apoptosis[95]