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Fig. 1 | Parasites & Vectors

Fig. 1

From: Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia

Fig. 1

Evaluation of conserved motifs and phylogenetic analysis of Giardia and Leishmania FPPS sequences. Multiple sequence alignment by MAFFT v7.397 used the CLUSTAL format. First aspartate rich motif (FARM), marked with a red line: alignment of 11 organisms (a); alignment of trypanosomatid parasites and Giardia FPPS protein sequences (b). Second aspartate rich motif (SARM), highlighted with red line: alignment comparing 11 organisms (c); alignment of trypanosomatid parasites and Giardia FPPS protein sequences (d). C-terminal region of FPPS (e). Identical residues are highlighted in black, and similar amino acid residues are marked in yellow. Amino acids involved with binding sites (red cross); residues involved in the chain length of the product (red arrow). Phylogenetic tree, constructed with the maximum likelihood method (f)

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Parasites & Vectors

ISSN: 1756-3305

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