An immunoinformatic approach driven by experimental proteomics: in silico design of a subunit candidate vaccine targeting secretory proteins of Leishmania donovani amastigotes

Table 2 List of MHC I epitopes with characteristic affinity and coverage

Epitope No.	Epitope sequence	Protein ID	Starting position	HLA supertype coverage	Tappred binding	VaxiJen score	IEDB class I score	No. of HLA alleles	World TPC (%)	Epitope conservancy^a in other Leishmania spp. in RefSeq database	Self^b
H1-01	LLYGGIFCY	E9B882	260	A1, A2, A3, A26, B58, B62	High	2.40	0.26	8	41.37	L. major, L. infantum, L. braziliensis, L. mexicana, L. guyanensis	No
H1-02	KIYANWPTY	E9BS02	189	A3, A26, B58, B62	High	1.41	0.25	15	63.11	L. major, L. infantum, L. mexicana	No
H1-03	FVAYFRTPL	E9BS02	77	A2, B7, B8, B39, B62	Medium	0.91	0.19	21	85.48	L. major, L. infantum, L. mexicana	No
H1-04	FVKWNFTAF	E9BI90	122	A24, A26, B7, B8, B62	Medium	1.08	0.31	16	67.98	L. infantum	No
H1-05	FMHVYTTHF	E9BIV4	119	A1, B8, B58, B62	Medium	0.77	0.14	19	83.44	L. major, L. infantum, L. mexicana	No
H1-06	HVYTTHFAY	E9BIV4	121	A1, A3, A26, B8, B58, B62	High	0.73	0.23	19	73.51	L. major, L. infantum, L. mexicana	No
H1-07	YVAFVERLY	E9BQ40	345	A1, A3, A26, B62	Medium	1.39	0.30	13	51.83	L. major, L. infantum, L. mexicana, L. braziliensis, L. panamensis	No
H1-08	RVAAALRIY	E9BUW4	58	A1, A3, A26, B58, B62	High	0.77	0.20	12	51.08	L. major, L. infantum, L. mexicana	No
H1-09	ATYAALLPL	E9BUW4	450	A2, B7, B58, B62	High	0.77	0.05	19	80.33	L. major, L. infantum, L. mexicana, L. braziliensis, L. panamensis	No

ISSN: 1756-3305