Insecticide susceptibility of the sand fly leishmaniasis vector Phlebotomus argentipes in Sri Lanka

Parasites & Vectors

Table 2 Mean activity/quantity of insecticide-detoxifying enzymes and remaining activity of propoxur-inhibited AChE in Phlebotomus argentipes (n ≥ 200)

Population	Insecticide metabolizing enzyme activity			Target site activity
	Esterase activity (µmol min⁻¹ mg⁻¹)	Glutathione S-transferase activity (µmol min⁻¹ mg⁻¹)	Monooxygenase amount^a	AChE^b
	Mean ± SE	Mean ± SE	Mean ± SE	Mean ± SE
Mamadala	0.108 ± 0.0093	0.198 ± 0.0145	0.0074 ± 0.0004	24.6 ± 1.690^c
Thalawa	0.105 ± 0.0093	0.221 ± 0.0166	0.0067 ± 0.0004	24.1 ± 1.700^c
Pannala	0.106 ± 0.0093	0.198 ± 0.0145	0.0069 ± 0.0004	23.5 ± 1.540^c
Mirigama	0.069 ± 0.0046	0.172 ± 0.0105	0.0059 ± 0.0003	12.6 ± 0.837**

^aEquivalent units of cytochrome P450
^bRemaining activity of propoxur-inhibited AChE given as a percentage of the activity of un-inhibited fraction
^cValues comparable with each other (F_{(2, 594)} = 0.12, P = 0.890)
^**Significantly different from values in the other three sites (F_{(3, 792)}v14.75, P < 0.0001)
Abbreviation: SE, standard error of the mean

ISSN: 1756-3305