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Table 3 Logistic regression of the appearance of nodules

From: Individuals living in an onchocerciasis focus and treated three-monthly with ivermectin develop fewer new onchocercal nodules than individuals treated annually

Variables

Saturated model

Stepwise model

OR(95% CI)

P-value

OR (95% CI)

P-value

Appearance of nodule(s) (yes/no)

Less than 5 nodules:

 150 µg/kg 3-monthly (n = 66)

Ref.

 

Ref.

 

 150 µg/kg annually (n = 77)

1.6 (0.6–3.8)

0.32

1.6 (0.7–3.8)

0.28

 800 µg/kg 3-monthly (n = 54)

2.6 (0.8–7.7)

0.092

2.6 (0.9–7.9)

0.082

 800 µg/kg annually (n = 58)

0.9 (0.4–2.1)

0.777

0.9 (0.4–2.2)

0.871

More than 5 nodules

 150 µg/kg 3-monthly (n = 59)

0.8 (0.3–1.9)

0.619

0.9 (0.4–2.0)

0.736

 150 µg/kg annually (n = 49)

3.5 (0.9–13.3)

0.066

4.1 (1.1–15.3)

0.034

 800 µg/kg 3-monthly (n = 58)

1.2 (0.4–2.9)

0.759

1.3 (0.5–3.2)

0.577

 800 µg/kg annually (n = 64)

5.2 (1.4–19.5)

0.014

5.5 (1.5–20.1)

0.01

Age

1.0 (1.0–1.0)

0.872

  

Weight

1.0 (1.0–1.0)

0.661

  

CMFL in the village of residence

 Low

Ref.

   

 Middle

1.2 (0.5–2.9)

0.704

  

 High

1.3 (0.6–3.0)

0.537

  

MFD

 0–30 mf/mg

Ref.

   

 31–80 mf/mg

1.3 (0.6–2.6)

0.459

  

 81–170 mf/mg

1.2 (0.6–2.4)

0.624

  

 > 171 mf/mg

1.7 (0.8–3.7)

0.151

  
  1. Abbreviations: OR, odds-ratio; 95% CI, 95% confidence interval; n, number of subjects; CMFL, community microfilarial load; MFD, microfilarial density; Ref., reference