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Table 3 Logistic regression of the appearance of nodules

From: Individuals living in an onchocerciasis focus and treated three-monthly with ivermectin develop fewer new onchocercal nodules than individuals treated annually

VariablesSaturated modelStepwise model
OR(95% CI)P-valueOR (95% CI)P-value
Appearance of nodule(s) (yes/no)
Less than 5 nodules:
 150 µg/kg 3-monthly (n = 66)Ref. Ref. 
 150 µg/kg annually (n = 77)1.6 (0.6–3.8)0.321.6 (0.7–3.8)0.28
 800 µg/kg 3-monthly (n = 54)2.6 (0.8–7.7)0.0922.6 (0.9–7.9)0.082
 800 µg/kg annually (n = 58)0.9 (0.4–2.1)0.7770.9 (0.4–2.2)0.871
More than 5 nodules
 150 µg/kg 3-monthly (n = 59)0.8 (0.3–1.9)0.6190.9 (0.4–2.0)0.736
 150 µg/kg annually (n = 49)3.5 (0.9–13.3)0.0664.1 (1.1–15.3)0.034
 800 µg/kg 3-monthly (n = 58)1.2 (0.4–2.9)0.7591.3 (0.5–3.2)0.577
 800 µg/kg annually (n = 64)5.2 (1.4–19.5)0.0145.5 (1.5–20.1)0.01
Age1.0 (1.0–1.0)0.872  
Weight1.0 (1.0–1.0)0.661  
CMFL in the village of residence
 LowRef.   
 Middle1.2 (0.5–2.9)0.704  
 High1.3 (0.6–3.0)0.537  
MFD
 0–30 mf/mgRef.   
 31–80 mf/mg1.3 (0.6–2.6)0.459  
 81–170 mf/mg1.2 (0.6–2.4)0.624  
 > 171 mf/mg1.7 (0.8–3.7)0.151  
  1. Abbreviations: OR, odds-ratio; 95% CI, 95% confidence interval; n, number of subjects; CMFL, community microfilarial load; MFD, microfilarial density; Ref., reference