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Fig. 5 | Parasites & Vectors

Fig. 5

From: Actin-related protein Arp4 regulates euchromatic gene expression and development through H2A.Z deposition in blood-stage Plasmodium falciparum

Fig. 5

PfArp4 knockdown disrupted the H3K9ac distribution at euchromatic gene loci. a Average profile of H3K9ac enrichment (log2[H3K9ac ChIP-normalized read coverage/input-normalized read coverage]) of PfArp4-Ty1-Ribo line with (right) versus without (left) GlcN at ring stage for H2A.Z-dependent or H2A.Z-independent genes, respectively. b Track view showing the H3K9ac signals in one representative H2A.Z-dependent gene PF3D7_0104300. c Boxplot showing the H3K9ac enrichment (log2[H3K9ac ChIP-normalized read coverage/input-normalized read coverage]) of H2A.Z-dependent genes (left) and H2A.Z-independent genes (right) are both significantly decreased with PfArp4 knockdown. Wilcoxon signed-rank test, Z = − 168.311; P-value < 2.2e-16; Wilcoxon signed-rank test, Z = − 63.162 (left); P-value < 2.2e-16 (right)

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