Fig. 8
From: IL-33/ST2 axis is involved in disease progression in the spleen during Leishmania donovani infection
Expression of FoxP3 in the spleen during L. donovani infection in mice treated or not with rIL-33. Immunohistochemical staining of spleen tissue sections of B6 (a) and BALB/c (b) mice using an anti-FoxP3 antibody, at the indicated time points in treated and untreated mice with rIL-33. Representative fields observed at 200× magnification by optic microscopy. Quantification of FoxP3 mRNA induction in spleen biopsies at various time points following infection of B6 (c) and BALB/c (e) in treated and untreated mice. Representative data (mean ± SE) of at least two experiments (**P < 0.01, 2-way ANOVA comparison). FoxP3 mRNA induction was highly correlated to splenic parasite burdens in B6 mice (Spearman correlation: P < 0.01) (d). Scale-bars: a, b, 250 µm