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Table 2 Mutations associated with kdr in ticks and insects

From: Physiological evidence that three known mutations in the para-sodium channel gene confer cypermethrin knockdown resistance in Rhipicephalus microplus

Domain Nucleotide position Nucleotide substitution Amino acid substitution Identified by Standardized PCR assay Organism and additional information (cited in)
II Susceptible population 148 C→T Leu→Phe [13] None R. microplus
II (super-kdr) 170 T→C Met→Thr [13] [13] Originally identified in Musca domestica. R. microplus [28,29,30]
II 184 G→C Gly→Arg [13] None R. microplus (Present study; [31,32,33]). This SNP occurs only in resistant poplulations that carry SNP T2134A
II Segment S4–5 linker 190 C→A Leu→Ile [16] R. microplus [16] R. microplus (Present study, [13, 34])
II 190 C→G Leu→Val [13] None R. microplus (Present study)
II Segment S4–5 linker 215 G→T Gly→Val [35] [12] R. microplus
III 2130 C→T Silent [13] None R. microplus
III Segment S6 2134 T→A Phe→Ile [14] [31, 36] R. microplus (Present study, [31,32,33]). This SNP occurs only in resistant populations that carry SNP G184C [13]
III 2157 G→T Gly→Gly (Silent)   None R. microplus (Present study)