Table 2 Mutations associated with kdr in ticks and insects
Domain | Nucleotide position | Nucleotide substitution | Amino acid substitution | Identified by | Standardized PCR assay | Organism and additional information (cited in) |
|---|---|---|---|---|---|---|
II Susceptible population | 148 | C→T | Leu→Phe | [13] | None | R. microplus |
II (super-kdr) | 170 | T→C | Met→Thr | [13] | [13] | Originally identified in Musca domestica. R. microplus [28,29,30] |
II | 184 | G→C | Gly→Arg | [13] | None | R. microplus (Present study; [31,32,33]). This SNP occurs only in resistant poplulations that carry SNP T2134A |
II Segment S4–5 linker | 190 | C→A | Leu→Ile | [16] | R. microplus [16] | |
II | 190 | C→G | Leu→Val | [13] | None | R. microplus (Present study) |
II Segment S4–5 linker | 215 | G→T | Gly→Val | [35] | [12] | R. microplus |
III | 2130 | C→T | Silent | [13] | None | R. microplus |
III Segment S6 | 2134 | T→A | Phe→Ile | [14] | R. microplus (Present study, [31,32,33]). This SNP occurs only in resistant populations that carry SNP G184C [13] | |
III | 2157 | G→T | Gly→Gly (Silent) | None | R. microplus (Present study) |