Fig. 3

Course of parasitemia (mean ± standard deviation) in BALB/c mice inoculated with 1 × 10⁷Babesia microti and treated with either vehicle, artesunate (ARS) 25 mg/kg, mefloquine (MEF) 10 mg/kg or 50 mg/kg, artesunate (ARS) 25 mg/kg + mefloquine (MEF) 10 mg/kg or 50 mg/kg (5 mice per group). Drugs were dissolved in 5% sodium bicarbonate (ARS) or 20% ethanol in polyethylene glycol in water (MEF) and administered intraperitoneally. ARS was given daily for 5 days starting at day 4 of infection (green arrows) and MEF was given in alternate days (days 4, 6 and 8: red arrows). Parasitemia was determined by microscopy. No significant differences in the course of parasitemia were observed between the groups