Fig. 3From: Anopheles metabolic proteins in malaria transmission, prevention and control: a reviewParaoxon binds conserved residues in both humans’ and mosquitoes’ acetylcholinesterase (AChE), hence toxic to humans. Diethyl phosphonate (DEP) from paraoxon binds covalently to Ser203 in humans AChE (hAChE; PDB ID: 5hf5) and Ser360 in An. gambiae AChE (AgAChE; PDB ID: 5x61), thus inhibiting them. Covalent binding is highlighted in black dotted circle. Also, DEP interacts with Gly122, His447 and Ala204 in hAChE, Gly280, His600 and Ala361 in AgAChE through hydrogen bondsBack to article page