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Table 3 Efficacy of pyrethoids and synergist mixture in insecticide treated nets

From: Anopheles metabolic proteins in malaria transmission, prevention and control: a review

Reference

Mosquito strain & (location)

Pyrethroid resistance intensity

Insecticide treated net (ITNs)

Mortality at 72 h# (%)

Blood-feeding inhibition# (%)

Personal protection### (%)

Pyrethroid

Pyrethroid + PBO

Untreated nets

Pyrethroid

Pyrethroid + PBO

Pyrethroid

Pyrethroid + PBO

Pyrethroid

Pyrethroid + PBO

Unwashed

Washed 20 times

Unwashed

Washed 20 times

Menze et al. [238]

An. funestus (Mibellon, Cameroon)

Mortality rates of around 48.88 ± 5.76% for permethrin and around 38.34 ± 5.79% for deltamethrin [270]

Olyset

Olyset Plus

5.4a

9.7a

nd

25.1

nd

62.37b

55.63b

83.01d

77.35d

PermaNet 2.0

PermaNet 3.0

12.2

nd

30.1

nd

51.36

61.52

70.44c

84.90c

Oumbouke et al. [239]

An. gambiae (s.s.) (Côte d’Ivoire)

Mortality rates of 68% for alpha-cypermethrin

MAGNet®

VEERALIN®

2.3

29

17.3

51

38.2

35.5

62.7

69

87.1

Toe et al. [271]

Anopheles gambiae (s.l.) (Burkina Faso)

Mortality rates of < 14% for permethrin and < 33% for deltamethrin

PermaNet 2.0

PermaNet 3.0

9.5

25.9

nd

46.1

nd

nd

nd

nd

nd

Olyset

Olyset Plus

21.8

nd

36.9

nd

nd

nd

nd

nd

Pennetier et al. [237]

An. gambiae (s.l.) (Malanville, Benin)

 

Olyset

Olyset Plus

0

42a

36a

81b

67b

82

83

nd

nd

Corbel et al. [235]

An. gambiae (s.s.) (Vallée du Kou, Burkina Faso)

23% mortality to deltamethrin L1014F kdr mutation (> 80%)

PermaNet 2.0

PermaNet 3.0

4.9

44.4a

30.2

78.2

49.3a

53.4

72.6

83

86

(Malanville, Benin)

85% mortality to deltamethrin. 16% L1014F kdr mutation Metabolic resistance (oxidase)

4.2

88.8

70.7a

96.7

70.0a

90.1

98.7

91.6

99.1

(Pitoa, Cameroon)

70% mortality to deltamethrin. < 5% L1014F kdr mutation. Metabolic resistance (oxidase + esterase)

12.9

82.9a

56.5

93.8

77.9a

70.8

46.1

92.3

80.4

  1. Abbreviations: nd, not determined in the study; PBO, piperonyl butoxide. For each column (#, ##, and ###), where provided, numbers in the same row (from the same study) sharing a letter superscript do not differ significantly (P > 0.05). The insecticide contained in each ITN are as follows: Olyset contains Permethrin; Olyset Plus contains Permethrin + PBO; PermaNet 2.0 contains Deltamethrin; PermaNet 3.0 contains Deltamethrin + PBO; MAGNet® contains Alpha-cypermethrin; VEERALIN® contains Alpha-cypermethrin + PBO