Fig. 4

H&E-stained liver sections of S. mansoni-infected non-treated mice. a Preserved hepatic architecture and multiple numerous closely packed necrotic and exudative-productive granulomas (×100). b A granulomatous reaction formed of inflammatory cells mainly eosinophils (short arrows), neutrophils (long arrows) and histiocytes (arrowheads) (×400). c Brownish schistosomal pigment (arrow) (×100). d Kupper cell hyperplasia (arrows) (×400). e Fatty change of hepatocytes (arrow) (×100). f Liver section of S. mansoni-infected mice treated with the higher dose fixed combination (Subgroup Iab) showing small-sized healing granulomas (×100)