Fig. 2

TEM observation of splenocytes in mice infected with B. microti at different stages. a 0 day (control); b 5 days; c 8 days; d 11 days; e 19 days. The number of mitochondria in mouse splenocytes infected by B. microti was significantly decreased. On the 8th day, the endoplasmic reticulum was obviously dilated, which was accompanied by degranulation. On the 11th day, the numbers of lysosomes increased, and the endoplasmic reticulum was still dilated, which was accompanied by degranulation. By the 19th day after infection, the expansion of the endoplasmic reticulum was significantly reduced, the degranulation was also weakened, and the number of lysosomes returned to the normal level. The short arrow points to mitochondria, the pentagram to the lysosome, the triangle to the endoplasmic reticulum and long scissors to autophagy