Table 1 Overview on study designs of the three laboratory studies
Study | Inoculation dose (L3) | Inoculation (study day) | Study group | Treatment | Study day | Necropsy (study day) |
|---|---|---|---|---|---|---|
1 | 800 | 0 | 1.1 | Placebo | 36 | 62–66 |
1.2 | Advocate® | 36 | ||||
2 | 300 | 0 | 2.1 | Untreated control | 136–140 | |
2.2 | Advocate® | − 10; 18 | ||||
2.3 | Advocate® | 53; 81; 109 | ||||
3 | 300 | 0 | 3.1 | Placebo | − 4; 24 | 48–50 (20 cats) |
3.2 | Advocate® | − 4; 24 | 34–35 (12 cats) | |||
3.3 | Advocate® | − 10; 18 | 48–50 | |||
3.4 | Advocate® | − 20; 8 | 48–50 |