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Table 1 Arithmetic mean tick counts and percent efficacy relative to placebo following one oral treatment with Simparica Trio™ for dogs with existing Amblyomma americanum infestations and after subsequent weekly re-infestations

From: Efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against induced infestations of five common tick species infesting dogs in the USA

StudyTick strainDayaPlacebobSimparica Trio™b% EfficacyTest statistic
MeanRangeMeanRange
1Bertek Inc.c219.03–3200–0100t(18) = 6.24, P < 0.0001
723.114–3800–0100t(18) = 10.08, P < 0.0001
1420.713–3300–0100t(18) = 9.10, P < 0.0001
2123.114–3700–0100t(18) = 9.12, P < 0.0001
2820.913–290.10–199.5t(18) = 10.05, P < 0.0001
3529.720–440.10–199.7t(18) = 13.08, P < 0.0001
2Ecto Services Incd317.712–270.10–199.4t(9.06) = 10.07, P < 0.0001
823.712–350.10–199.6t(9.06) = 10.10, P < 0.0001
1516.15–2500–0100t(9) = 9.11, P < 0.0001
2213.97–2300–0100t(9) = 9.80, P < 0.0001
2912.49–160.20–198.4t(9) = 16.78, P < 0.0001
3614.44–250.10–199.3t(9.05) = 7.32, P < 0.0001
  1. aFirst infestation on Day -2. Subsequent infestations on Day 5, 12, 19, 26 and 33. Tick counts were conducted at 48 (Study 1) or 72 (Study 2) hours post-treatment and subsequent re-infestation
  2. bTreatment with placebo or Simparica Trio™ (minimum dose 1.2 mg/kg sarolaner, 24 µg/kg moxidectin and 5 mg/kg pyrantel (as pamoate salt)) occurred on Day 0
  3. cColony originated from ticks field-collected in Greenbrier, AR, USA, in 2009 and was last supplemented with wild-caught ticks ~ 3 years prior to study start
  4. dColony originated from ticks field-collected in Stillwater, OK, USA, in 2011 and was last supplemented with field-collected ticks ~ 4 months prior to study start