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Table 2 Arithmetic mean tick counts and percent efficacy relative to placebo following one oral treatment with Simparica Trio™ for dogs with existing Amblyomma maculatum infestations and after subsequent weekly re-infestations

From: Efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against induced infestations of five common tick species infesting dogs in the USA

StudyTick strainDayaPlacebobSimparica Trio™b% EfficacyTest statistic
MeanRangeMeanRange
3Oklahoma State Universityc230.03–7400–0100t(9) = 4.78, P = 0.0010
733.814–500.10–199.7t(9) = 8.12, P < 0.0001
1430.115–440.10–199.7t(9.02) = 10.61, P < 0.0001
2132.612–470.20–299.4t(9.05) = 8.58, P < 0.0001
2823.66–420.30–298.7t(9.06) = 6.27, P = 0.0001
3523.16–450.70–297.0t(9) = 6.31, P = 0.0001
4Texas A&M Universityd235.111–500.30–299.1t(9.05) = 8.51, P < 0.0001
726.30–450.30–298.9t(9.04) = 5.43, P = 0.0004
1433.914–5400–0100t(17) = 8.14, P < 0.0001
2128.913–460.70–497.6t(9) = 7.24, P < 0.0001
2825.013–372.40–1590.4t(9) = 9.14, P < 0.0001
3525.76–516.10–1876.3t(9) = 5.23, P = 0.0005
  1. aFirst infestation on Day -2. Subsequent infestations on Day 5, 12, 19, 26 and 33. Tick counts were conducted at 48 hours post-treatment and weekly re-infestation
  2. bTreatment with placebo or Simparica Trio™ (minimum dose 1.2 mg/kg sarolaner, 24 µg/kg moxidectin and 5 mg/kg pyrantel (as pamoate salt)) occurred on Day 0
  3. cColony originated from ticks field-collected in Stillwater, OK, USA, in 1991 and was last supplemented with wild-caught ticks ~ 15 months prior to study start
  4. dColony originated from ticks field-collected in Refugio Co., TX, USA, in the mid-1980s and was last supplemented with wild-caught ticks ~ 2 years prior to study start