Count time^{a} | Treatment group | Day^{b} |
---|

0 | 7 | 14 | 21 | 28 | 35 |
---|

8 hours | Placebo | 18.1 | 20.7^{d} | 21.6 | 19.1 | 17.7 | 17.7 |

Simparica Trio™ | 5.9 | 8.0^{d} | 17.1 | 13.9 | 17.1 | 16.8 |

% Efficacy | 67.5 | 61.5^{d} | 20.6 | 27.3 | 3.1 | 5.0 |

Test statistic | *t*_{(9.71)} = 2.19 | *t*_{(6.99)} = 5.18 | *t*_{(40)} = 0.84 | *t*_{(12.3)} = 1.29 | *t*_{(13.7)} = 0.23 | *t*_{(7.68)} = 0.75 |

*P-*value^{c} | 0.0545 | 0.0013 | 0.4069 | 0.2191 | 0.8186 | 0.4751 |

12 hours | Placebo | 21.3 | 23.6 | 18.9 | 21.2^{d} | 24.9 | 19.6 |

Simparica Trio™ | 0.3 | 3.6 | 7.7 | 8.0^{d} | 11.9 | 10.9 |

% Efficacy | 98.4 | 84.9 | 59.4 | 62.2^{d} | 52.2 | 44.3 |

Test statistic | *t*_{(13.2)} = 18.10 | *t*_{(9.39)} = 6.21 | *t*_{(40)} = 4.00 | *t*_{(6.6)} = 4.32 | *t*_{(13.8)} = 1.79 | *t*_{(13.3)} = 2.27 |

*P-*value^{c} | < 0.0001 | 0.0001 | 0.0003 | 0.0040 | 0.0957 | 0.0404 |

24 hours | Placebo | 17.4 | 17.2 | 24.1 | 16.8 | 23.1 | 14.8 |

Simparica Trio™ | 0.1 | 0.1 | 0.0 | 0.3 | 1.3 | 4.8 |

% Efficacy | 99.4 | 99.4 | 100 | 98.0 | 94.2 | 67.7 |

Test statistic | *t*_{(9.29)} = 9.34 | *t*_{(9.04)} = 11.33 | *t*_{(40)} = 12.89 | *t*_{(9.29)} = 7.98 | *t*_{(8.03)} = 9.62 | *t*_{(9.12)} = 4.22 |

*P-*value^{c} | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | 0.0022 |

^{a}Time after treatment or subsequent weekly tick infestations^{b}Day of treatment (Day 0) and of subsequent weekly tick infestations^{c}*P-*value for comparison of arithmetic mean tick counts between Simparica Trio™ and placebo groups at each time point within a row, *P* ≤ 0.05 indicates significant difference^{d}Time point with missing observations, back-transformed least squares means and corresponding percent efficacy estimates were used