Parasites & Vectors

Table 1 Arithmetic mean of live tick counts and percent efficacy relative to placebo for dogs treated once orally with Simparica Trio™ at 1.2 mg/kg sarolaner, 24 µg/kg moxidectin and 5 mg/kg pyrantel (as pamoate salt)

From: Evaluation of the speed of kill of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against induced infestations of Ixodes scapularis on dogs

Count time^a	Treatment group	Day^b
Count time^a	Treatment group	0	7	14	21	28	35
8 hours	Placebo	18.1	20.7^d	21.6	19.1	17.7	17.7
	Simparica Trio™	5.9	8.0^d	17.1	13.9	17.1	16.8
	% Efficacy	67.5	61.5^d	20.6	27.3	3.1	5.0
	Test statistic	t_(9.71) = 2.19	t_(6.99) = 5.18	t₍₄₀₎ = 0.84	t_(12.3) = 1.29	t_(13.7) = 0.23	t_(7.68) = 0.75
	P-value^c	0.0545	0.0013	0.4069	0.2191	0.8186	0.4751
12 hours	Placebo	21.3	23.6	18.9	21.2^d	24.9	19.6
	Simparica Trio™	0.3	3.6	7.7	8.0^d	11.9	10.9
	% Efficacy	98.4	84.9	59.4	62.2^d	52.2	44.3
	Test statistic	t_(13.2) = 18.10	t_(9.39) = 6.21	t₍₄₀₎ = 4.00	t_(6.6) = 4.32	t_(13.8) = 1.79	t_(13.3) = 2.27
	P-value^c	< 0.0001	0.0001	0.0003	0.0040	0.0957	0.0404
24 hours	Placebo	17.4	17.2	24.1	16.8	23.1	14.8
	Simparica Trio™	0.1	0.1	0.0	0.3	1.3	4.8
	% Efficacy	99.4	99.4	100	98.0	94.2	67.7
	Test statistic	t_(9.29) = 9.34	t_(9.04) = 11.33	t₍₄₀₎ = 12.89	t_(9.29) = 7.98	t_(8.03) = 9.62	t_(9.12) = 4.22
	P-value^c	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	0.0022

^aTime after treatment or subsequent weekly tick infestations
^bDay of treatment (Day 0) and of subsequent weekly tick infestations
^cP-value for comparison of arithmetic mean tick counts between Simparica Trio™ and placebo groups at each time point within a row, P ≤ 0.05 indicates significant difference
^dTime point with missing observations, back-transformed least squares means and corresponding percent efficacy estimates were used

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ISSN: 1756-3305

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