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Table 2 Parasitological parameters, lung pathology and preventive drug efficacy against larvae excretion and (pre-)adult of Aelurostrongylus abstrusus

From: Efficacy of Bravecto® Plus spot-on solution for cats (280 mg/ml fluralaner and 14 mg/ml moxidectin) for the prevention of aelurostrongylosis in experimentally infected cats

Group

Animal ID

First day of L1 excretion (dpi)

Max. L1 count/day in 5 g faeces

GM of max. L1 count/day

Efficacy (%)

Lung pathology score

(Pre-)adult worm count

GM of adult worms

Preventive efficacy (%)

1 (treated 12 weeks prior to infection)

0801

n.a.

0

1.10

99.99

1

0

0.09

99.66

1054

39

5

0

0

2936

n.a.

0

1

0

3881

37

1

0

0

5300

n.a.

0

1

1

6615

n.a.

0

0

0

8860

39

31

1

0

9657

n.a.

0

0

0

2

(treated 8 weeks prior to infection)

0370

n.a.

0

1.19

99.99

0

0

0.00

100

3599

36

1

0

0

5820

n.a.

0

2

0

6242

37

25

1

0

6554

n.a.

0

0

0

7273

42

9

0

0

7707

n.a.

0

1

0

8219

n.a.

0

0

0

3

(treated 4 weeks prior to infection)

0862

n.a.

0

0.53

99.98

0

0

0.00

100

1160

n.a.

0

0

0

1291

n.a.

0

0

0

3550

41

1

1

0

6179

44

9

0

0

6676

n.a.

0

0

0

9914

n.a.

0

1

0

4

(untreated control)

1151

33

45,900

7574.29

99.99

3

23

26.57

n.a.

1465

36

7400

3

36

1509

40

54

4

10

1588

38

1200

3

15

6407

33

43,100

4

64

6646

33

45,300

3

56

9013

36

11,300

3

23

9335

32

21,900

3

23

  1. dpi = day post infection, max. = maximum, GM = geometric mean, n.a. = not applicable