Deworming women of reproductive age during adolescence and pregnancy: what is the impact on morbidity from soil-transmitted helminths infection?

Table 2 Average prevalences of moderate- and high-intensity infections in women of reproductive age

Model^a	Age period (years)	SB only, mean (95% credible interval)	SB + WRA, mean (95% credible interval)	% Reduction, mean (95% credible interval)^b	P value
ICL	15–50	0.0216 (0.0142–0.0328)	4.81 × 10⁻³ (2.35 × 10⁻³–8.57 × 10⁻³)	77.8 (59.2–91.9)	< 2.2 × 10⁻¹⁶
ICL	15–19	0.101 (0.06–0.141)	0.0173 (3.33 × 10^-3–0.03)	83.5 (66.7–95.9)	< 2.2 × 10⁻¹⁶
ICL	20–50	8.828 × 10⁻³ (3.88 × 10⁻³–0.0127)	2.73 × 10⁻³ (5.54 × 10⁻⁴–5.57 × 10⁻³)	61.5 (− 22.6 to 100)	< 2.2 × 10⁻¹⁶
EMC	15–50	5.06 (4.54–5.46)	3.90 (3.47–4.26)	23.0 (20.1–26.0)	< 2.2 × 10⁻¹⁶
EMC	15–19s	4.42 (3.93–4.85)	2.00 (1.70–2.35)	55.2 (50.6–60.3)	< 2.2 × 10⁻¹⁶
EMC	20–50	5.16 (4.66–5.59)	4.21 (3.78–4.59)	18.3 (15.0–21.7)	< 2.2 × 10⁻¹⁶

Values in table are presented as the mean prevalence (%)
^aModerate baseline prevalence (20–50%) and annual SB treatment. The FoI inputted into the cohort model was extracted from the ICL and EMC fully stochastic individual-based models with annual ongoing SB treatment, i.e. FoI decreased over time. In the ICL model prevalences of moderate- and high-intensity infections (M&HI) infections in WRA are well below 1%. Therefore, the reduction in the prevalence of M&HI infections in absolute numbers is negligible and the uncertainty large
^bThe relative reduction is only calculated from time points where the prevalence of M&HI infections in simulations with the old treatment strategy (SB only) is > 0. All time points were used in the statistical comparison.

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