Table 1 Synergists and corresponding doses used for the experiments
Drug | Mechanism of action | D A (C max) (ng/ml) | D B (75% of C max) (ng/ml) | DC (50% of C max) (ng/ml) | D D (25% of C max) (ng/ml) |
|---|---|---|---|---|---|
Cobicistat [31] | Dual CYP/P-gp inhibitora | 990 | 742 | 495 | 247 |
Cyclosporine A [32] | Selective P-gp inhibitorb | 1802 | 1351 | 901 | 450 |
Elacridar [33] | Selective P-gp inhibitor | 160 | 120 | 80 | 40 |
Rifampicin [34] | Dual CYP/P-gp inducer | 7000 | 5250 | 3500 | 1750 |
Ritonavir [35] | Dual CYP/P-gp inhibitor | 11,000 | 8250 | 5500 | 2750 |
Voriconazole [36] | Dual CYP/P-gp inhibitor | 3667 | 2750 | 1833 | 916 |