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Table 1 Synergists and corresponding doses used for the experiments

From: Potential metabolic resistance mechanisms to ivermectin in Anopheles gambiae: a synergist bioassay study

Drug Mechanism of action DA (Cmax) (ng/ml) DB (75% of Cmax) (ng/ml) DC (50% of Cmax) (ng/ml) DD (25% of Cmax) (ng/ml)
Cobicistat [31] Dual CYP/P-gp inhibitora 990 742 495 247
Cyclosporine A [32] Selective P-gp inhibitorb 1802 1351 901 450
Elacridar [33] Selective P-gp inhibitor 160 120 80 40
Rifampicin [34] Dual CYP/P-gp inducer 7000 5250 3500 1750
Ritonavir [35] Dual CYP/P-gp inhibitor 11,000 8250 5500 2750
Voriconazole [36] Dual CYP/P-gp inhibitor 3667 2750 1833 916
  1. aWith effect markedly skewed towards CYP inhibition
  2. bNegligible effect on CYPs