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Table 3 Synergist drugs combined with ivermectin

From: Potential metabolic resistance mechanisms to ivermectin in Anopheles gambiae: a synergist bioassay study

Drug Synergist concentration (ng/ml) Mean survival time (95% CI) 10-day % mortality
Voriconazole    
 Control   8.5 (8.0–9.1) 21.9
 Ivermectin   8.0 (7.5–8.5) 35.0
 IVM + VOR A 3667 5.4 (4.9–5.9) 59.8
 IVM + VOR B 2750 5.7 (5.3–6.0) 44.9
 IVM + VOR C 1833 7.6 (7.0–8.1) 42.2
 IVM + VOR D 916 7.4 (6.9–7.8) 34.7
Ritonavir    
 Control   8.0 (7.5–8.4) 18.3
 Ivermectin   8.2 (7.7–8.8) 30.3
 IVM + RIF A 11,000 6.8 (6.1–7.5) 53.7
 IVM + RIF B 8250 6.6 (5.8–7.4) 51.8
 IVM + RIF C 5500 6.7 (6.1–7.3) 55.2
 IVM + RIF D 2750 7.3 (6.7–8.0) 42.3
Cobicistat    
 Control   7.1 (6.8–7.5) 18.5
 Ivermectin   7.8 (7.1–8.4) 45.6
 IVM + COB A 990 8.6 (8.1–9.1) 23.6
 IVM + COB B 742 8.2 (7.8–8.7) 29.6
 IVM + COB C 495 7.5 (6.9–8.1) 39.0
 IVM + COB D 247 8.1 (7.6–8.6) 30.8
Elacridar    
 Control   9.5 (9.3–9.8) 12.2
 Ivermectin   7.1 (6.5–7.6) 54.6
 IVM + ELA A 160 6.9 (6.4–7.4) 62.3
 IVM + ELA B 120 7.3 (6.8–7.8) 49.6
 IVM + ELA C 80 6.5 (6.1–7.0) 51.4
 IVM + ELA D 40 7.0 (6.5–7.4) 56.1
Cyclosporine A    
 Control   9.0 (8.3–9.6) 15.6
 Ivermectin   9.0 (8.5–9.6) 21.8
 IVM + CYC A 1802 7.8 (6.8–8.8) 34.7
 IVM + CYC B 1351 7.7 (6.8–8.6) 38.1
 IVM + CYC C 901 7.7 (7.0–8.4) 20.9
 IVM + CYC D 450 8.5 (7.9–9.2) 33.3
Rifampicin    
 Control   7.2 (6.6–7.7) 39.1
 Ivermectin   6.7 (6.0–7.5) 53.4
 IVM + RIF A 7000 6.9 (6.2–7.6) 49.5
 IVM + RIF B 5250 6.4 (5.6–7.1) 61.3
 IVM + RIF C 3500 8.2 (7.6–8.9) 31.5
 IVM + RIF D 1750 6.4 (5.8–7–0) 66.3
  1. IVM ivermectin, VOR voriconazole, RIF ritonavir, COB cobicistat, ELA elacridar, CYC cyclosporine A