Comparative preventive efficacy of ProHeart® 12, Heartgard® Plus and Interceptor® Plus against a macrocyclic lactone-resistant strain (JYD-34) of heartworm (Dirofilaria immitis) in dogs

Table 1 Study 1: ProHeart 12 compared to Heartgard Plus or Interceptor Plus against the JYD-34 heartworm strain: Design, day −30 heartworm inoculation

Group	Treatment	Dosage	Number of dogs	Day of L3 D. immitis inoculation ^a	Days of treatment	Days of blood MF and adult D. immitis AG testing	Day of necropsy and adult D. immitis worm recovery
T01	Negative control	NA	6	−30	0	−36, 61, 121^c, 151, 178	185 (215 days PI)
T02	ProHeart 12	0.5 mg/kg moxidectin^b	6	−30	0
T03	Heartgard Plus	Min. of 6 µg/kg ivermectin ^b	6	−30	0, 30, 60, 90, 120, 150
T04	Interceptor Plus	Min. of 0.5 mg/kg milbemycin oxime ^b	6	−30	0, 30, 60, 90, 120, 150

^aEach dog was inoculated with 50 D. immitis third-stage larvae (JYD-34 strain)
^bProHeart 12, Heartgard Plus (ivermectin + pyrantel) and Interceptor Plus (milbemycin oxime + praziquantel) administered at their approved dosages according to their commercial label directions
^cOn day 121 only adult D. immitis AG testing was conducted

ISSN: 1756-3305