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Table 2 Mean monthly milbemycin oxime dose (mg/kg) received in the adult and juvenile target animal safety studies

From: Long-term and acute safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) in juvenile and adult dogs

Study

Dose level

Mean milbemycin oxime dose (mg/kg)

Dose cycle 1

Dose cycle 2

Dose cycle 3

Dose cycle 4

Dose cycle 5

Dose cycle 6

Dose cycle 7

Dose cycle 8

Dose cycle 9

Adult

1X

1.35

1.27

1.39

1.34

1.32

1.36

1.34

N/A

N/A

3X

4.11

4.03

3.99

4.02

4.15

4.04

4.07

N/A

N/A

5X

6.74

6.67

6.91

6.74

6.82

6.73

6.73

N/A

N/A

Juvenile

1X

1.67

1.32

1.32

1.29

1.34

1.31

1.32

1.38

1.30

3X

4.46

4.15

4.12

3.80

3.94

4.21

3.95

4.16

4.07

5X

7.48

6.66

6.76

6.71

6.76

6.68

6.49

6.60

6.60

  1. N/A: Not applicable
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Parasites & Vectors

ISSN: 1756-3305

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