Skip to main content

Table 1 Effectiveness of a single oral dose of a novel chewable tablet (Credelio Plus) containing milbemycin oxime and lotilaner against induced L4 larval and immature adult [L5] Toxocara canis infections in dogs

From: Effectiveness of Credelio® Plus, a novel chewable tablet containing milbemycin oxime and lotilaner for the treatment of larval and immature adult stages of Toxocara canis in experimentally infected dogs

Study Stage at time of treatment Day of inoculationa Day of treatment Day of necropsy (worm recovery) Treatment group n No. of infected dogs Worm count range Geometric worm count Effectiveness compared to vehicle control
% efficacy Effectiveness P-value
1 L4 larvae 0 14 19 Vehicle control 10 7 0–20 4.8
      Credelio Plusb 10 0 0–0 0 100 < 0.001
2 L4 larvae 0 14 20 Vehicle control 10 10 2–51 9.9
      Credelio Plusb 10 3 0–3 0.3 96.8 < 0.001
1 Immature adult [L5] 0 24 30 Vehicle control 10 10 4–72 22.1
      Credelio Plus b 10 4 0–1 .3 98.6 < 0.001
2 Immature adult [L5] 0 24 30 Vehicle control 10 10 5–67 22.3
      Credelio Plus b 10 4 0–2 0.4 98.3 < 0.001
  1. n number of animals per group
  2. aEach dog was inoculated with ca. 250 infective T. canis eggs
  3. bCredelio Plus provided minimum dosages of 0.89 to 1.0 mg/kg of milbemycin oxime in both studies