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Table 3 Effectiveness of a single oral dose of Credelio Plus against natural nematode infections in dogs presenting to European veterinary clinics

From: Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) against natural intestinal nematode infections in dogs presented as veterinary patients in Europe

NNematode species Samplea Treatment groupb Number of dogs Egg count per gram faeces
Geometric Mean (GM) GM % reduction Number of dogs with zero eggs (%) Effectiveness P-valuec
All nematode species Pre-treatment Credelio Plus
Afoxolaner + MO
278
117
13.2
11.2



Post-treatment Credelio Plus
Afoxolaner + MO
278
117
0.3
0.3
97.6
97.0
245 (88.2%)
99 (84.6%)
 < 0.0001 (t524 = 24.33)
 < 0.0001 (t524 = 14.65)
Toxocara canis Pre-treatment Credelio Plus
Afoxolaner + MO
54
19
16.4
8.0



Post-treatment Credelio Plus
Afoxolaner + MO
54
19
0.5
0.4
97.2
95.3
48 (88.9%)
16 (84.2%)
 < 0.0001 (t79.3 = 4.36)
 < 0.0001 (t79.3 = 9.70)
Ancylostoma caninum Pre-treatment Credelio Plus
Afoxolaner + MO
109
42
11.2
9.9



Post-treatment Credelio Plus
Afoxolaner + MO
109
42
0.2
0.5
98.1
95.3
100 (91.7%)
35 (83.3%)
 < 0.0001 (t185 = 9.28)
 < 0.0001 (t185 = 17.19)
Trichuris vulpis Pre-treatment Credelio Plus
Afoxolaner + MO
176
80
9.8
9.7



Post-treatment Credelio Plus
Afoxolaner + MO
176
80
0.2
0.1
97.8
98.5
156 (88.6%)
73 (91.2%)
 < 0.0001 (t340 = 12.79)
 < 0.0001 (t340 = 18.57)
  1. MO milbemycin oxime
  2. aPre-treatment sample collected once on Day 0; post-treatment sample collected on Day 8 (range 7–10)
  3. bSingle oral administration of Credelio Plus on Day 0 to provide a dose range of 0.75–1.56 mg/kg bodyweight MO and 20.0–41.5 mg/kg bodyweight lotilaner. Single oral dose of Nexgard Spectra on Day 0 to provide a dose range of 2.50–5.36 mg/kg bodyweight of afoxolaner and 0.50–1.07 mg/kg bodyweight of MO
  4. cEffectiveness P-value is the P-value for the within-treatment difference in least-square means