Fig. 3

TLR4 pathway activation stimulated the COX2/PGE2 axis in Sj-infected mice. TLR4 signaling in C57BL/6 mice was inhibited by intraperitoneal injection of TAK242 once a day from weeks 4 to 8 after Sj infection. a The protein expression level of mPGES-1, EP2, and EP4 in mice liver homogenates tested by western blotting is shown on the left, and semi-quantitative results are displayed on the right. b Concentration of serum ALB in TAK242-treated or untreated mice with or without Sj infection was detected by the bromocresol green colorimetric method (t test, **P < 0.01, ns, no significance). c Concentration of LPS in sera of mice with indicated time courses was detected by ELISA (ordinary one-way ANOVA followed by Dunnett’s multiple comparisons test, **P < 0.01). Data are presented as mean ± SEM from 7 to 10 mice per group. All experiments were performed twice