Fig. 3

Analysis of differentially expressed proteins (DEPs). a Volcano plot of DEPs. This plot depicts volcano plot of log2 fold change (x-axis) versus -log10 P-value (y-axis, representing the probability that the protein is differentially expressed) of the 581 proteins identified in the iTRAQ. P-value < 0.05 and fold-change > 1.2 are set as the significant threshold for differential expression. The red and green dots indicate points-of-interest that display both large-magnitude fold-changes as well as high statistical significance. Dots in red indicate significantly upregulated proteins which passed the screening threshold. Dots in green indicate significantly downregulated proteins which passed the screening threshold. Black dots indicate nonsignificant DEPs. b GO analysis of downregulated DEPs. X-axis: Names of different GO terms. Y-axis: The number of downregulated DEPs. c GO analysis of upregulated DEPs. X-axis: Names of different GO terms. Y-axis: The number of upregulated DEPs. d KEGG analysis of downregulated DEPs. X-axis: Names of different KEGG pathways. Y-axis: The number of downregulated DEPs. e KEGG analysis of upregulated DEPs. X-axis: Names of different KEGG pathways. Y-axis: The number of upregulated DEPs