Fig. 1

Histological changes in the pancreas of dogs seropositive for anti-Leishmania infantum antibodies with chronic (a–d) and acute to subacute (e–f) pancreatitis. a Moderate diffuse granulomatous pancreatitis composed mainly of macrophages, with a smaller number of plasma cells and lymphocytes. b Higher magnification of the previous figure showing many macrophages, with a smaller number of plasma cells and lymphocytes and Leishmania spp. amastigotes (arrow and inset) within the cytoplasm of a macrophage in the interstitial tissue amid the inflammatory infiltrate. c Severe granulomatous pancreatitis composed mainly of macrophages, with a smaller number of lymphocytes, plasma cells, and eosinophils. Fibrosis and a nematode larva (arrowhead and inset) are also seen in the parenchyma. d Severe interstitial lymphoplasmacytic pancreatitis (arrows and inset) consisting mainly of lymphocytes and plasma cells. e Severe perivascular eosinophilic pancreatitis (arrows and inset) composed mainly of eosinophils, with few lymphocytes and plasma cells. f Severe perivascular suppurative pancreatitis (asterisks and inset) consisting mainly of neutrophils, with many lymphocytes and plasma cells and few macrophages. Hematoxylin–eosin staining (a–f)