Table 2 Final pharmacokinetic and pharmacodynamic model parameters

V_PQ, l (70 kg)

130

6.05

CL_H1, l/h (70 kg)

25.1

8.78

CL_H2, l/h (70 kg)

5.6

29.6

MAT, h

0.915

11.2

IIV CL^#, CV%

46

30.6

IIV V_PQ, CV%

44

26.5

IIV MAT, CV%

55

28.8

Proportional error, %

25.3

20.0

Additive error, ng/ml^a

2

–

Lifespan, h

276

50

Slope, C_CYP2D6⁻¹·h⁻¹

0.0012

49

F_G6PDd

2.46

103

Proportional error Hb, V%

6.95

4