Insights from Leishmania (Viannia) guyanensis in vitro behavior and intercellular communication

Parasites & Vectors

Table 1 Enhancement of the Sb(III) IC₅₀ for the less sensitive strain after growth under media sharing

Co-cultured strain	Tested strain	IC₅₀ (µM)^a	Previous IC₅₀ (µM)^a	Difference from the control (%) (P-value)
IOC-L2335R	IOC-L2335C	18.81 ± 4.81	24.20 ± 6.66	− 22.31 (P = 0.24)
IOC-L2372F	IOC-L2370C	113.67 ± 3.56	35.36 ± 5.08	221.46 (P < 0.0001)

^aIC₅₀ for Sb(III) of the tested strains (IOC-L 2335C and 2370C). Three biological replicates were assayed, and the means with the standard deviations are shown. A t-test was performed for paired comparisons, and the P-values are shown between parentheses

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