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Table 1 Major ivermectin studies in humans

From: Ivermectin as an endectocide may boost control of malaria vectors in India and contribute to elimination

Trial name/first author of study(year) [reference] Dosage of ivermectin Results: mortality of mosquito
ACTIVE [24]
2013
Burkina Faso
200 µg/kg as a single dose or 200 µg/kg for 2 days as two doses or placebo; all administered with artemether-lumefantrine An. gambiae
Mortality of mosquito in 3 days post blood meal (one dose of Ivermectin): 33%
Mortality of mosquito in 3 days post blood meal (two doses of Ivermectin): 31%
Controls: 6% mortality in 3 days (difference was significant)
Mortality of mosquito in 10 days post blood meal (one dose of Ivermectin): 59%
Mortality of mosquito in 10 days post blood meal (2 doses of Ivermectin): 66%
Controls: 21% mortality in 10 days (difference was significant)
An. funestus
Mortality of mosquito in 3 days post blood meal (one dose of Ivermectin): 33%
Mortality of mosquito in 3-days post blood meal (two doses of Ivermectin): 22%
Controls: 3% mortality in 3 days (difference was significant)
Mortality of mosquito in 10 days post blood meal (one dose of Ivermectin): 40%
Mortality of mosquito in 10 days post blood meal (two doses of Ivermectin): 51%
Controls: 5% mortality in 10 days (difference was significant)
RIMDAMAL [15]
2015
Burkina Faso
First dose of 150–200 µg/kg single dose with 400 mg albendazole plus five further similar ivermectin doses at 3-week intervals Frequently repeated mass administration of ivermectin during the malaria transmission season led to significant reduction in malarial episodes in children
IVERMAL [25]
2015
Kenya
300 µg/kg for 3 days or 600 µg/kg for 3 days or placebo; all administered with dihydroartemisinin-piperaquine 3-Day ivermectin treatment at either of the doses reduced mosquito survival for at least 28-days-post feeding
Derua [26]
2015
Tanzania
150–200 μg/kg Mortality of mosquito in 3 days post blood meal: 66.2%
Mortality of mosquito in 9 days post blood meal: 95%
Significance not reported
Sampaio [27]
2016
Brazil
200 µg/kg Ivermectin treatment reduces mosquito survivorship by 4 h to 14 days
Kobylinski [28]
2017
Thailand
200 µg/kg Ivermectin was lethal to dominant GMS Anopheles malaria vectors and inhibited sporogony of P. vivax at safe human relevant concentrations
Mekuriaw [14]
2019
Ethiopia
Single oral dose of 12 mg Significant higher mortality of mosquitos on days 1 and day 4 reported